余凯凡

性    别

男

学历学位

研究生学历、理学博士学位

职    称

副教授

导师类别

硕士生导师

专业领域

动物营养与饲料科学

研究方向

动物营养与肠道微生物；植物提取物、微生态制剂等功能性饲料的研发与应用；特色饲料资源开发与应用

教育与工作经历

2013年09月至今，在南京农业大学动物科技学院任教；

2017年12月-2018年12月，美国贝勒医学院，儿童营养研究中心访学；

2010年09月-2013年06月，中山大学，生物学（生物技术）专业攻读博士；

2007年09月-2010年06月，华南农业大学，动物营养与饲料科学专业攻读硕士；

2003年09月-2007年06月，华南农业大学，动物科学专业攻读本科

联系方式

yukaifan@njau.edu.cn

奖励及荣誉

2018-2019学年“可莱威”奖教金；中国畜牧兽医学会动物营养学分会第四届青年学者讲坛优秀奖

参加学术团体及任职情况

中国畜牧兽医学会会员，中国畜牧兽医学会动物营养学分会会员

承担科研项目

1. 国家自然科学基金面上项目，2024.01-2027.12，在研，主持；

2. 国家自然科学基金面上项目，2019.01-2023.12，在研，主持；

3. 国家重点研发计划项目子课题，2021.12-2026.11，在研，主持；

4. 国家自然科学基金区域创新发展联合基金，2022.01-2025.12，在研，子任务负责人；

5. 国家自然科学基金青年项目，结题，主持；

6. 江苏省农业科技自主创新资金，结题，主持；

7. 中央高校基本科研业务费项目，结题，主持；

8. 南京农业大学联合项目，结题，主持；

9. 国家自然科学基金重点项目，31430082，结题，参加；

10. 国家自然科学基金面上项目，31572414，结题，参加。

论文论著：

近年主要研究方向为：基于肠道微生物及其活性代谢产物研究猪肠道健康的营养调控；植物提取物、微生态制剂等功能性饲料的研发与应用；特色饲料资源营养价值精准评价研究。热忱欢迎考生联系与报考！

1. 期刊论文

Li X, Huang G, Zhang Y, Ren Y, Zhang R, Zhu W, Yu K*. Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction. Pharmacological Research, 2023, 194: 106865

Zhang Y, Li X, Huang G, Wang H, Chen H, Su Y, Yu K*, Zhu W. Propionate stimulates the secretion of satiety hormones and reduces acute appetite in a cecal fistula pig model. Animal Nutrition. 2022, 10: 390-398

Li X, Ren Y, Huang G, Zhang R, Zhang Y, Zhu W, Yu K*. Succinate communicates pro-inflammatory signals to the host and regulates bile acid enterohepatic metabolism in a pig model. Food & Function, 2022, 13(21): 11070-11082

Zhang R, Huang G, Ren Y, Wang H, Ye Y, Guo J, Wang M, Zhu W, Yu K*. Effects of dietary indole-3-carboxaldehyde supplementation on growth performance, intestinal epithelial function, and intestinal microbial composition in weaned piglets. Frontiers in Nutrition. 2022, 9: 896815

Yu K^#, He Y^#, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Gourdy P, Arnal JF, Lenfant F, Xu Y*, Wang C*. 17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERɑ signaling. Molecular Metabolism. 2020, 42: 101053

Yu K, Zhang Y, Chen H, Zhu W*. Hepatic metabolomic and transcriptomic responses induced by cecal infusion of sodium propionate in a fistula pig model. Journal of Agricultural and Food Chemistry. 2019, 67(47): 13073-13081

Li X, Mao M, Zhang Y, Yu K*, Zhu W. Succinate modulates intestinal barrier function and inflammation response in pigs. Biomolecules. 2019, 9(9): E486

Zhang Y, Chen H, Zhu W, Yu K*. Cecal infusion of sodium propionate promotes intestinal development and jejunal barrier function in growing pigs. Animals. 2019, 9(6): E284

Zhang Y^#, Yu K^#*, Chen H, Su Y, Zhu W. Cecal infusion of the short chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model. Microbial Biotechnology. 2018, 11(5): 859–868

Yu K, Mu C, Yang Y, Su Y, Zhu W*. Segment-specific responses of intestinal epithelium transcriptome to in-feed antibiotics in pigs. Physiological Genomics. 2017, 49: 582-591

Mo D^#, Yu K^#, Chen H, Chen L, Liu X, He Z, Cong P, Chen Y*. Transcriptome landscape of porcine intramuscular adipocytes during differentiation. Journal of Agricultural and Food Chemistry. 2017, 65: 6317-6328

Yu K^#, Mo D^#, Wu M, Chen H, Chen L, Li M, Chen Y*. Activating transcription factor 4 regulates adipocyte differentiation via altering the coordinate expression of CCATT/enhancer binding protein β and peroxisome proliferator-activated receptor γ. FEBS Journal. 2014, 281(10): 2399-2409

Yu K^#, Shu G^#, Yuan F, Zhu X, Gao P, Wang S, Wang L, Xi Q, Zhang S, Zhang Y, Li Y, Wu T, Yuan L*, Jiang Q*. Fatty acid and transcriptome profiling of longissimus dorsi muscles between pig breeds differing in meat quality. International Journal of Biological Sciences. 2013, 9(1): 108-118

Ye H, Feng B, Wang C, Saito K, Yang Y, Ibrahimi L, Schaul S, Patel N, Saenz L, Luo P, Lai P, Torres V, Kota M, Dixit D, Cai X, Qu N, Hyseni I, Yu K, Jiang Y, Tong Q, Sun Z, Arenkiel BR, He Y*, Xu P*, Xu Y*. An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. Science Advances. 2022, 8(3): eabk0185

Yang Y*, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y*. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Reports. 2021, 37(10): 110075

Shen J, Mu C, Wang H, Huang Z, Yu K, Zoetendal EG, Zhu W.  Stimulation of Gastric Transit Function Driven by Hydrolyzed Casein Increases Small Intestinal Carbohydrate Availability and Its Microbial Metabolism. Molecular Nutrition & Food Research. 2020, 64(21): e2000250

He Y^#, Xu P^#, Wang C^#, Xia Y^#, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y*. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nature Communications. 2020, 11(1): 2165

Peng Y, Yu K, Mu C, Hang S, Che L, Zhu W*. Progressive response of large intestinal bacterial community and fermentation to the stepwise decrease of dietary crude protein level in growing pigs. Applied Microbiology and Biotechnology. 2017, 101(13):5415-5426

Mu C, Yang Y, Yu K, Yu M, Zhang C, Su Y, Zhu W*. Alteration of metabolomic markers of amino-acid metabolism in piglets with in-feed antibiotics. Amino Acids. 2017, 49(4): 771-781

Yu M, Zhang C, Yang Y, Mu C, Su Y, Yu K, Zhu W*. Long-term effects of early antibiotic intervention on blood parameters, apparent nutrient digestibility, and fecal microbial fermentation profile in pigs with different dietary protein levels. Journal of Animal Science and Biotechnology. 2017, 1(8): 60

Sun Y, Yu K, Zhou L, Fang L, Su Y*, Zhu W. Metabolomic and transcriptomic responses induced in the livers of pigs by the long-term intake of resistant starch. Journal of Animal Science. 2016, 94 (3): 1083-1094

毛明雨, 张若凡, 黄国文, 李轩, 成艳芬, 余凯凡*, 朱伟云. 猪源乳杆菌Lactobacillus reuteri strain DSM和Lactobacillus taiwanensis strain BCRC对肠道炎症的影响. 微生物学报. 2021, 61(11): 3715-3725

张亚南, 李轩, 陈慧子, 余凯凡*, 朱伟云. 丙酸钠对IPEC-J2细胞紧密连接及炎症细胞因子的影响. 南京农业大学学报. 2019, 42(1): 137-144

余凯凡, 张福哲, 朱伟云*. 猪不同肠段微生物体外培养对蛋氨酸的代谢特性. 微生物学报. 2018, 58(5): 784-792

张亚南, 余凯凡*, 朱伟云. 肠道微生物调控宿主食欲的研究进展. 微生物学报. 2017, 57(7): 951-960

余凯凡, 李思奇, 朱伟云*. 不同规模猪场饲料粗蛋白水平及赖氨酸添加量的研究. 畜牧与兽医. 2017, 49(10): 24-27

朱伟云*, 余凯凡, 慕春龙, 杨宇翔. 猪的肠道微生物与宿主营养代谢. 动物营养学报. 2014, 26(10): 3053-3058

 2. 会议论文

Yu K, Mu C, Yang Y, Zhu W. Transcriptomic responses in porcine intestinal epithelium induced by antibiotics. The 5th International Symposium on Gastrointestinal Microbial Ecology and Functionality, Hangzhou, China, 2016.05.23-05.25

Yu K, Mu C, Yang Y, Yu M, Su Y, Zhu W. Changes in gut microbiota induced by early antibiotic intervention modifies intestinal luminal amino acid metabolism in piglets. Amino Acids. 2015, 47(8): 1677. The 14th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria, 2015.08.03-08.07

朱伟云, 余凯凡. 猪利用氮营养素的机制及营养调控研究进展. 中国畜牧兽医学会动物营养学分会第十届全国代表大会暨十二届学术研讨会, 中国武汉, 2016.10.21-10.23