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教师目录-旧

张定东

来源: 发布时间 : 2021-06-10 点击量:

   

张定东

 

   

学历学位

研究生/工学博士

   

教授

导师类别

博导

专业领域

水产养殖

研究方向

营养表观遗传学;营养生理学;健康养殖与尾水治理

教育与工作经历

1、教育经历 (education background)

12003/09-2007/10,东南大学,生物科学与医学工程学院,生物医学工程博士

21998/09-2001/07,南京农业大学,渔业学院,水产养殖硕士

31994/09-1998/07,南京农业大学,渔业学院,淡水渔业本科

2、工作经历 (employment record)

12013/02-present,南京农业大学,动物科技学院,副教授、教授

22017/12-2018/12Vanderbilt University(范德堡大学,美国),School of Medicinethe U.S.A.Visiting Scholar

32010/09-2011/03University of Munich(慕尼黑大学,德国),Department of Medicine IIGermanyVisiting Scholar

42001/08-2013/02,金陵科技学院,动物科学与技术学院,讲师、副教授

联系方式

电话025-84399916办公室逸夫楼3045邮箱zdd_7597@njau.edu.cn

奖励及荣誉

1江苏省333高层次人才培养工程第三层次培养对象;

2)江苏省高校青蓝工程优秀青年骨干教师培养对象;

3)2013年度江苏省海洋与渔业科技创新奖三等奖(5/11);

4)2016年度江苏省科技进步奖二等奖(5/11);

5)2016年度江苏省海洋与渔业科技创新奖一等奖(3/11);

6)20162022年度动技学北正农奖教金;

72018年度中国水产科学研究院科技进步奖一等奖(11/20);

82019年度江苏省高层次创新创业人才引进计划科技副总

参加学术团体及任职情况

1)江苏省海洋湖沼学会理事;

2)江苏省水产学会会员;

3)中国营养学会会员;

承担科研项目

1江苏现代农业(大宗鱼类)产业技术体系JATS[2021]484,池塘养殖尾水治理岗位项目,2021/07-present30/年,主持

2)国家重点研发计划项目,2022YFD2400702,中华绒螯蟹、克氏原螯虾、螺蛳大规格抗逆新品种培育,2022/11-2026/1260万,子课题,主持

3)江苏省重点研发计划现代农业重点项目,BE2022366,大闸蟹养殖信息动态精准测控关键技术及智能装备研发,2022/07-2025/0630万,研究骨干

4)江苏省碳达峰碳中和科技创新专项资金,BE2022421,基于低碳饲料和环境调控的淡水池塘低碳养殖关键技术研究与示范,2022/07-2026/06研究骨干

5)南京市农业重大技术协同推广计划试点项目,2022RHCXY(04),特色鱼产业重大技术协同推广计划,2022/06-2023/05主持

6)全国农业科技现代化先行县(浦口区)共建项目,青虾产业提升工程,2021/11-2022/12主持

7江苏省种业振兴揭榜挂帅项目JBGS[2021]129,适应全程配合饲料的河蟹新品种培育,2022/01-2026/12主持

8江苏省农业科技自主创新项目,CX(20)3109,中华绒螯蟹一龄蟹种性早熟机制及防早熟饲料研究,2020/08-2022/07主持

9南京农业大学泰州研究院项目,水产养殖尾水生态治理科技示范,2020/01-2020/1210万,研究骨干

10国家自然科学基金(面上项目),31972801,高糖负荷下团头鲂CaSRGCGR沉默诱导的α-细胞增生中的作用,2020/01-2023/1258万,主持

11国家科技支撑项目2013BAD20B05,长三角现代农业区优质水产养殖技术集成与示范,2013/01-2015/1251万,课题主持

12)江苏省农业科技自主创新项目,CX(16)1004-09,池塘工业化养殖下鱼类营养品质调控技术研发与应用,2016/06-2019/06主持

13)江苏省农业科技自主创新项目,CX(15)1011-04,河蟹新品种营养需求与饲料研究关键技术集成,2015/06-2017/12主持

14)江苏省水产三新工程项目,Y2014-33,蟹池多品种混养模式下的饲料配套技术研究与集成示范,2014/03-2016/12主持

15农业部淡水渔业与种质资源利用重点实验室开放基金项目,KF201310miRNA及其靶基因在团头鲂免疫调控中的作用与机制研究,2013/07-2015/06主持

16国家自然科学基金(青年基金),60901053,尿沉淀细胞DNA甲基化高通量检测方法的研究,2010/01-2012/1220万,主持

17)苏宁现代农业股份有限公司横向),2014主持

18)江苏海普瑞饲料有限公司(横向),2019/07-2023/12主持

论文论著:

一、发表论文Selected publications*corresponding author# co-first author

2013 – Present (focus on aquatic animal nutrition and nutri-epigenetics)                                   

1. Yulong Gong#, Bingyuan Yang#, Dingdong Zhang, Yue Zhang, Zihan Tang, Liu Yang, Katie C. Coate, Linlin Yin, Brittney A. Covington, Ravi S. Patel, WalterA. Siv, Katelyn Sellick, Matthew Shou, WenhanChang, E. Danielle Dean, Alvin C. Powers, Wenbiao Chen*. Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways. Nature Communications, 2023, 14:235.

2. Weibo Jiang, Xiaoyan Jia, Ningjun Xie, Chuang Wen, Shuo Ma, Guangzhen Jiang, Xiangfei Li, Cheng Chi, Dingdong Zhang*, Wenbin Liu*. Fermentation feed enhances dietary nutritional composition and attraction, meal flavor, and intestinal microbiota of Chinese mitten crab (Eriocheir sinensis). Animal Nutrition, 2023 (in press).

3. Chuang Wen, Shuo Ma, Hongyan Tian, Weibo Jiang, Xiaoyan Jia, Wuxiao Zhang, Guangzhen Jiang, Xiangfei Li, Cheng Chi, Chaofan He, Wenbin Liu, Dingdong Zhang*. Evaluation of the protein-sparing effects of carbohydrates in the diet of the crayfish, Procambarus clarkii. Aquaculture, 2022, 556:738275.

4. Erteng Jia, Weibo Jiang, Wenbin Liu, Guangzhen Jiang, Xiangfei Li, Cheng Chi, Dingdong Zhang*. Crowding stress-related protein markers: New candidates for assessing welfare of largemouth bass reared in an in-pond raceway system. Aquaculture, 2022, 550:737821.

5. Xiaoyan Jia, Chang He, Weibo Jiang, Chuang Wen, Fan Gao, Guangzhen Jiang, Xiangfei Li, Cheng Chi, Wenbin Liu*, Dingdong Zhang*. Identification of potential pathways whereby dietary L-tryptophan ameliorates the glucose metabolic disorder of blunt snout bream through long non-coding RNAs. Aquaculture, 2021, 545:737256.

6. Fan Gao#, Mingyang Liu#, Jianqing Tang, Aimin Wang, Hongyan Tian, Chuang Wen, Cheng Chi, Guangzhen Jiang, Xiangfei Li, Wenbin Liu, Dingdong Zhang*. Partial replacement of dietary fish oil by beef tallow does not impair antioxidant capacity and innate immunity of red swamp crayfish, Procambarus clarkii. Aquaculture Research. 2021, 00:1-12.

7. Chang He, Xiaoyan Jia, Li Zhang, Fan Gao, Weibo Jiang, Chuang Wen, Cheng Chi, Xiangfei Li, Guangzhen Jiang, Haifeng Mi, Wenbin Liu, Dingdong Zhang*. Dietary berberine can ameliorate glucose metabolism disorder of Megalobrama amblycephala exposed to a high-carbohydrate diet. Fish Physiology and Biochemistry, 2021, 47:499-513.

8. Fan Gao, Jie Liu, Aimin Wang, Bo Liu, Hongyan Tian, Xiaochuan Zheng, Xiaoyan Jia, Chang He, Xiangfei Li, Guangzhen Jiang, Cheng Chi, Wenbin Liu, Dingdong Zhang*. Dietary lipid sources modulate the intestinal transport of fatty acids in the red swamp crayfish Procambarus clarkii. Aquaculture, 2020, 521:735091.

9. Jie Liu, Erteng Jia, Huajuan Shi, Xiangfei Li, Guangzhen Jiang, Cheng Chi, Wenbin Liu, Dingdong Zhang*. Selection of reference genes for miRNA quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy metabolism in Megalobrama amblycephala. Fish Physiology and Biochemistry, 2019, 45:1663-1681.

10. Hongyan Tian, Dingdong Zhang*, Xiangfei Li, Guangzhen Jiang, Wenbin Liu. Photoperiod affects blunt snout bream (Megalobrama amblycephala) growth, diel rhythm of cortisol, activities of antioxidant enzymes and mRNA expression of GH/IGF-I. Comparative Biochemistry and Physiology, Part B, 2019, 233:4-10.

11. Jean‐Jacques Yao Adjoumani, Kenneth Prudence Abasubong, Francis Phiri, Chao Xu, Wenbin Liu, Dingdong Zhang*. Effect of dietary betaine and choline association on lipid metabolism in blunt snout bream fed a high‐fat diet. Aquaculture Nutrition, 2019, 25:1017-1027.

12. Erteng Jia, Xiaochuan Zheng, Huihui Cheng, Jie Liu, Xiangfei Li, Guangzhen Jiang, Wenbin Liu, Dingdong Zhang*. Dietary fructooligosaccharide can mitigate the negative effects of immunity on Chinese mitten crab fed a high level of plant protein diet. Fish and Shellfish Immunology, 2019, 84:100-107.

13. Erteng Jia#, Yanan Yan#, Man Zhou, Xiangfei Li, Guangzhen Jiang, Wenbin Liu, Dingdong Zhang*. Combined effects of dietary quercetin and resveratrol on growth performance, antioxidant capability and innate immunity of blunt snout bream (Megalobrama amblycephala). Animal Feed Science and Technology, 2019, 256:114268.

14. Si-lei Xia, Xiang-fei Li, Kenneth Prudence Abasubong, Chao Xu, Hua-juan Shi, Wen-bin Liu*, Ding-dong Zhang*. Effects of dietary glucose and starch levels on the growth, apparent digestibility, and skin-associated mucosal non-specific immune parameters in juvenile blunt snout bream (Megalobrama amblycephala). Fish and Shellfish Immunology, 2018, 79:193-201.

15. Dingdong Zhang*, Yanan Yan, Hongyan Tian, Guangzhen Jiang, Xiangfei Li, Wenbin Liu. Resveratrol supplementation improves lipid and glucose metabolism in high-fat diet-fed blunt snout bream. Fish Physiology and Biochemistry, 2018, 44:163-173. (高被引论文)

16. 贾二腾,闫明军,赖起铖,罗文涛,蒋广震,刘文斌,张定东*. 中华绒螯蟹的摄食节律. 中国水产科学,2018,25(3):546-554.

17. Jean-Jacques Yao Adjoumani, Kaizhou Wang, Man Zhou, Wenbin Liu, Dingdong Zhang*. Effect of dietary betaine on growth performance, antioxidant capacity and lipid metabolism in blunt snout bream fed a high-fat diet. Fish Physiology and Biochemistry, 2017, 43:1733-1745

18. Erteng Jia, Zhuoqin Li, Yunfei Xue, Guangzhen Jiang, Xiangfei Li, Wenbin Liu, Dingdong Zhang*. Effects of dietary fructooligosaccharide on the growth, antioxidants, immunity and disease resistance of Chinese mitten crab. Aquaculture, 2017, 481:154-161.

19. 闫亚楠,夏斯蕾,田红艳,徐超,贾二腾,刘文斌,张定东*. 白藜芦醇对高脂胁迫团头鲂抗氧化能力、非特异免疫机能和抗病力的影响. 水生生物学报,2017,41(1):155-164.

20. 张定东,李俊怡,王冰柯,李向飞,蒋广震,李鹏飞,蔡万存,刘文斌*. 胆碱对高脂胁迫的团头鲂肝脏抗氧化、组织结构和免疫力的影响. 水产学报,2017,41(3):438-447.

21 Kang-Le Lu#, Ding-Dong Zhang#, Li-Na Wang, Wei-Na Xu, Wen-Bin Liu*. Molecular characterization of carnitine palmitoyltransferase IA in Megalobrama amblycephala and effects on its expression of feeding status and dietary lipid and berberine. Comparative Biochemistry and Physiology, Part B, 2016, 191:20-25.

22. Dingdong Zhang, Kangle Lu, Guangzhen Jiang, Wenbin Liu*, Zaijie Dong*, Hongyan Tian, Xiangfei Li. A global transcriptional analysis of Megalobrama amblycephala revealing the molecular determinants of diet-induced hepatic steatosis, Gene, 2015, 570(2):255-263.

23. Hong-Yan Tian, Ding-Dong Zhang*, Chao Xu, Fei Wang, Wen-Bin Liu*. Effects of light intensity on growth, immune responses, antioxidant capability and disease resistance of juvenile blunt snout bream Megalobrama amblycephala. Fish and Shellfish Immunology, 2015, 47(2):674-680.

24. Hongyan Tian, Dingdong Zhang*, Xiangfei Li, Chunnuan Zhang, Yu Qian, Wenbin Liu*. Optimum feeding frequency of juvenile blunt snout bream Megalobrama amblycephala. Aquaculture, 2015, 437:60-66.

25. Dingdong Zhang, Kangle Lu, Zaijie Dong*, Guangzhen Jiang, Weina Xu, Wenbin Liu*. The effect of exposure to a high-fat diet on microRNA expression in the liver of blunt snout bream (Megalobrama Amblycephala). PLoS One, 2014, 9 (5):e96132.

 

2003-2012 (design specific microarrays to identify DNA methylation markers for early diagnosis)

1. Min Pan, Qinyu Ge, Hailing Li, Qi Yang, Jiafeng Lu, Dingdong Zhang, Zuhong Lu*. Sequencing the miRNAs in maternal plasma from women before and after parturition. Journal of Nanoscience and Nanotechnology, 2012, 12:1–9.

2. Yunfei Bai, Dai Lin, Qin Han, Yaojuan Jia, Jing Tu, Junfeng Luo, Qinyu Ge, Dingdong Zhang, Zuhong Lu*. Discrimination of single nucleotide mutation by using a new class of immobilized shared-stem double-stranded DNA probes. Journal of Biomedical Nanotechnology, 2011, 7:1–8.

3. Yao Yang, Wei Wang, Yanqiang Li, Jing Tu, Yunfei Bai, Pengfeng Xiao, Dingdong Zhang, Zuhong Lu*. Identification of methylated regions with peak search based on Poisson model from massively parallel methylated DNA immunoprecipitation sequencing data. Electrophoresis, 2010, 31:3537–3544.

4. Dingdong Zhang#, Yan Wang#, Yunfei Bai, Qinyu Ge, Yingjuan Qiao, Junfeng Luo, Chao Jia, Zuhong Lu*. A novel method to quantify local CpG methylation density by regional methylation elongation assay on microarray. BMC Genomics, 2008, 9:59.

5. Yan Wang#, Dingdong Zhang#, Wenli Zheng, Junfeng Luo, Yunfei Bai, Zuhong Lu*. Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. Cancer, 2008, 112:1325-1336.

6. Dingdong Zhang#, Yunfei Bai#, Yan Wang, Junfeng Luo, Qinyu Ge, Yingjuan Qiao, Chao Jia, Zuhong Lu*. Detailed methylation patterns and protein expression profiles of MGMT in colorectal carcinoma surgical margins. Clinical Biochemistry, 2008, 41(1-2):19-25.

7. Qinyu Ge, Yunfei Bai, Dingdong Zhang, Zuhong Lu*. Microarray Detection of Fetal DNA Levels in Maternal Plasma. Analytical Letters, 2007, 40:1540-1548.

8. Qinyu Ge, Zhaobin Liu, Yunfei Bai, Dingdong Zhang, Pinfei Yu, Zuhong Lu*. Emulsion PCR-based method to detect Y chromosome microdeletions. Analytical Biochemistry, 2007, 367(2):173-178.

9. Zhixiang Wu, Junfeng Luo, Qinyu Ge, Dingdong Zhang, Yan Wang, Chao Jia, Zuhong Lu*. Allele-specific extension on microarray for DNA methylation analysis. Analytica Chimica Acta, 2007, 603(2):199-204.

10.Dingdong Zhang, Yunfei Bai, Qinyu Ge, Yingjuan Qiao, Yan Wang, Zaozao Chen, Zuhong Lu*. Microarray-based molecular margin methylation pattern analysis in colorectal carcinoma. Analytical Biochemistry, 2006, 355(1):117-124.

11.Yan Wang, Wenli Zheng, Junfeng Luo, Dingdong Zhang, Zuhong Lu*. In situ bisulfite modification of membrane-immobilized DNA for multiple methylation analysis. Analytical Biochemistry, 2006, 359(2):183-188.

12.Wenli Zheng, Yan Wang, Dingdong Zhang, Junfeng Luo, Zuhong Lu, A microarray to analyze methylation patterns of E-cad gene 5’CpG islands, 4’th International Forum of Post-Genome Technologies (IFPT’4), 286~290, September 25-26, 2006, Hangzhou, China.

 

二、专利 (Patents)

1. 张定东,刘文斌,徐维娜,蒋广震,李向飞,孙存鑫,蔡万存. 一种鱼粉替代物及其制备方法与应用. 专利号:ZL201610013390.5 (20191105)

2. 张定东,姜维波,刘文斌,何超凡,李向飞,蒋广震,迟骋,刘恒彤. 一种青虾短途零售运输装置. 实用新型专利,专利号:ZL202220877440.52022715日)

3. 张定东,贾晓燕,刘文斌,何超凡,李向飞,蒋广震,迟骋,刘恒彤. 一种青虾短途运输笼. 实用新型专利,专利号:ZL202220970611.92022726日)

4. 孙存鑫,张定东,刘文斌,徐维娜,蒋广震,李向飞. 一种渔用复合型诱食剂及其制备方法与应用. 专利号:ZL201610104835.0 (20200825)

5. 徐维娜,刘文斌,张定东,蒋广震,鲁康乐,秦钦.一种改善黄颡鱼鱼苗食性转换期肠道功能的微生态饲料.专利号:ZL201310103740.3 (2014507)

6. 李向飞,刘文斌,徐超,蒋广震,张定东. 一种改善鱼体糖耐受性的调控组合物及其制备方法与应用. 专利号:ZL201510811938.6 (20190226)

7. 蒋广震, 刘文斌, 周嫚, 李向飞, 张定东. 一种以甘草提取物为主的调控剂、及其制备方法与应用. 专利号:ZL201510843107.7 (20181123)

8. 李向飞,刘文斌,王冰柯,蒋广震,张定东. 一种渔用糖代谢调控物及其制备方法与应用. 专利号:ZL201610261110.22018918日)

9. 蒋广震;刘文斌;李向飞;张定东;米海峰;吴业阳. 一种维生素强化的团头鲂抗逆饲料的维生素添加剂.专利号:ZL201610215215.4 (20191112)

10. 刘文斌;何超凡;李向飞;张定东;蒋广震;郑肖川;黄洋洋;何畅. 一种浮性膨化饲料专用食台. 实用新型专利,专利号:ZL201922190568.5 (20210105)

11. 刘文斌;何超凡;李向飞;张定东;蒋广震;迟骋;张玲;郑肖川. 一种大型中华绒螯蟹分极装置. 实用新型专利,专利号:ZL202121775002.X20211214日)

12. 刘文斌;何超凡;李向飞;张定东;蒋广震;迟骋;张玲;郑肖川. 一种便携式中华绒螯蟹水瘪子检测装置. 实用新型专利,专利号:ZL202121754172.X20211210日)

13. 刘文斌;何超凡;李向飞;张定东;蒋广震;迟骋;张玲;郑肖川. 一种鳊鱼投料监测用鱼重量称重装置. 实用新型专利,专利号:ZL202121754292.X 20211123日)

14. 刘文斌;何超凡;李向飞;张定东;蒋广震;迟骋;刘恒彤. 一种水产养殖试验用饲料同步投喂装置. 实用新型专利,专利号:ZL202220989516.3 20220805日)

15. 李向飞;张玲;刘文斌;何超凡;张定东;蒋广震;迟骋;刘恒彤. 一种青虾零售短期维生装置. 实用新型专利,专利号:ZL202220922828.2 20220719日)

16.刘文斌;何超凡;李向飞;张定东;蒋广震;迟骋;张玲;郑肖川. 中华绒螯蟹品质分级控制系统V1.0,软件著作权,登记号:2021SR1179022.

17.刘文斌;何超凡;李向飞;张定东;蒋广震;迟骋;张玲;郑肖川. 团头鲂投料监测调控系统V1.0. 软件著作权,登记号:2021SR1177663.

18. 刘文斌;何超凡;李向飞;张定东;蒋广震;迟骋;张玲;郑肖川. 便携式中华绒螯蟹水瘪子检测系统V1.0. 软件著作权,登记号:2021SR1177664.

 

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