张羽

性    别

女

学历学位

研究生学历、农学博士学位

职    称

副研究员

导师类别

硕士生导师

专业领域

动物遗传育种与繁殖

研究方向

动物卵子成熟与胚胎发育

教育与工作经历

2004年9月-2009年6月，南京农业大学，动物医学专业攻读本科

2009年9月-2011年6月，南京农业大学，临床兽医专业攻读硕士

2011年9月-2014年12月，南京农业大学，临床兽医专业攻读博士

2015年3月-至今，在南京农业大学动物科技学院任教

联系方式

zhangyu77@njau.edu.cn

奖励及荣誉

2023年教育部自然科学二等奖（3/6）

2019年教育部自然科学二等奖（5/5）

动科院2021年青年教师授课比赛“特等奖”

动科院2020年教师授课比赛“二等奖”

动科院2021年优秀毕业论文指导教师

参加学术团体及任职情况

中国畜牧兽医学会会员；江苏省研究型医院学会生殖医学专业委员会委员

承担科研项目

1. 国家自然科学基金委员会, 面上项目, 32372878, 2024/01/01-2027/12/31，50万元，主持

2. 国家自然科学基金委员会, 面上项目, 31972615, 2020/01/01-2023/12/31，59万元，参与

3. 中央高校基本科研业务费，学科建设专项，XUEKEN2022007， 2022/01-2022/12，14万元，主持

4. 中央高校基本科研业务费， KYCXJC2022001，2022/01-2022/12，50万元，参加

5. 中央高校基本科研业务费，KYYZ202102, 2021/01/01-2021/12/31，5万元，主持

6. 国家自然科学基金青年基金项目，31601204，2017/01-2019/12，22万元，主持。

7. 江苏省自然科学基金青年基金项目，BK20150674，2015/07-2018/06，20万元，主持

8. 中国博士后科学基金面上资助，2015M580441，2015/12-2017/11，8万元，主持

9. 江苏省博士后科研资助计划，1501065B，2015/08/25-2017/08/24，4万元，主持

10. 南京农业大学专任教师科研启动费，802558，2015/10-2017/10，1万元，主持

11. 中央高校基本科研业务费，KJQN201703，2016/01-2018/12，10万元，主持

12. 博士后国际交流计划学术交流项目，2015，3万元，主持

论文论著：

张羽，博士，副研究员，2015年03月至今在南京农业大学动物科技学院任教。主要开展哺乳动物卵母细胞质量控制与分子调控的机制研究，研究包括环境污染物和环境应激对卵母细胞成熟质量的影响机制。

1. 代表作（第一作者/通讯作者）：

1 Xing CH, Chen S, Wang Y, Pan ZN, Zou YJ, Sun SC, Ren ZL, Zhang Y*. Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs. J Anim Sci Biotechnol, 2022 Jul 8;13(1):80.

2 Xing CH, Wang Y, Liu JC, Pan ZN, Zhang HL, Sun SC, Zhang Y*. Melatonin reverses mitochondria dysfunction and oxidative stress-induced apoptosis of Sudan I-exposed mouse oocytes. Ecotoxicol Environ Saf. 2021 Dec 1;225: 112783.

3 Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC*. RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis. Mol Hum Reprod. 2019, 25(7):359-372.

4 Zhang Y, Wang T, Lan M, Sun SC*. Melatonin protects oocytes from MEHP exposure-induced meiosis defects in porcine. Biol Reprod. 2018, 98(3): 286-298.

5 Zhang Y, Wang F, Niu YJ, Liu HL, Rui R, Cui XS, Kim NH, Sun SC*. Formin mDia1, a downstream molecule of FMNL1, regulates Profilin1 for actin assembly and spindle organization during mouse oocyte meiosis. BBA Mol Cell Res. 2015, 1853(2): 317-27.

2. 发表论文（第一作者/通讯作者）

1 Jiao L, Hu CX, Zhang Y, Zhang YX, Cai WW, Pan WL, Sun Shao-CS, Zhang Yu*. SIRT3 Regulates Levels of Deacetylated SOD2 to Prevent Oxidative Stress and Mitochondrial Dysfunction During Oocyte Maturation in Pigs. Microsc Microanal. 2023 Dec 21;29(6):2149-2160.

2 Zhang Y, Wu LL, Wan X, Wang HH, Li XH, Pan ZN, Sun SC*. Loss of PKC mu function induces cytoskeletal defects in mouse oocyte meiosis. J Cell Phyisol. 2019, 234(10):18513-18523.

3 Zhang Y, Wang HH, Wan X, Xu Y, Pan MH, Sun SC*. Inhibition of protein kinase D disrupts spindle formation and actin assembly during porcine oocyte maturation. Aging. 2018, 10(12):3736-44.

4 Zhang Y, Wang QC, Liu J, Xiong B, Cui XS, Kim NH, Sun SC*. The Small GTPase CDC42 regulates actin dynamics during porcine oocyte maturation. J Reprod Dev. 2017, 63(5): 505-510.

5 Lu YJ#; Zhang Y#, Pan MH, Kim NH, Sun SC*, Cui XS*. Daam1 regulates fascin for actin assembly in mouse oocyte meiosis. Cell Cycle, 2017, 16(14): 1350-1356.

6 Ma RJ#, Li HR#, Zhang Y#, Lin Y, Qiu XH, Xie M, Yao B*. The toxic effects and possible mechanisms of Brusatol on mouse oocytes. PloS One, 2017, 12(5): e0177844.

7 Zhang Y#, Zhu CC#, Sun SC. Cyclin B3: an anaphase onset controller in meiosis. Cell Cycle, 2015, 14(19): 3013.

8 Zhang Y, Duan X, Cao R, Liu HL, Cui XS, Kim NH, Rui R, Sun SC*. Small GTPase RhoA regulates cytoskeleton dynamics during porcine oocyte maturation and early embryo. Cell Cycle. 2014, 13(21): 3390-403.

9 Zhang Y, Liu J, Peng X, Zhu CC, Han J, Luo J, Rui R*. KIF20A Regulates Porcine Oocyte Maturation and Early Embryo Development. PLoS One. 2014, 9(7): e102898.

10 Zhang Y, Wang QC, Han J, Cao R, Cui XS, Kim NH, Rui R, Sun SC*. Involvement of Dynamin 2 in actin-based polar body extrusion during porcine oocyte maturation. Mol Reprod Dev. 2014, 81(8):725-34.

11 Zhang Y, Duan X, Xiong B, Cui XS, Kim NH, Rui R, Sun SC*. ROCK inhibitor Y-27632 prevents porcine oocyte maturation. Theriogenology. 2014, 82(1):49-56.

3. 参与发表论文：

1 Liu JC, Xing CH, Xu Y, Pan ZN, Zhang HL, Zhang Y, Sun SC*. DEHP exposure to lactating mice affects ovarian hormone production and antral follicle development of offspring. J Hazard Mater. 2021 Aug 15;416:125862.

2 Pan ZN, Pan MH, Sun MH, Li XH, Zhang Y, Sun SC*. RAB7 GTPase regulates actin dynamics for DRP1-mediated mitochondria function and spindle migration in mouse oocyte meiosis. FASEB J. 2020, 34(7): 9615-9627.

3 Pan MH, Wan X, Wang HH, Pan ZN, Zhang Y, Sun SC*. FMNL3 regulates FASCIN for actin-mediated spindle migration and cytokinesis in mouse oocytes. Biol Reprod. 2020, 102(6): 1203-1212.

4 Lan M, Zhang Y, Wan X, Pan MH, Xu Y, Sun SC*. Melatonin ameliorates ochratoxin A-induced oxidative stress and apoptosis in porcine oocytes. Environ Pollut. 2020. 256:113374

5 Wang QC, Wan X, Jia RX, Xu Y, Liu X, Zhang Y, Sun SC*. Inhibition of N-WASP affects actin-mediated cytokinesis during porcine oocyte maturation. Theriogenology. 2020, 144:132-138.

6 Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC*. Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics. Development. 2019. 146(3): dev171280.

7 Pan ZN, Lu Y, Tang F, Pan MH, Wan X, Lan M, Zhang Y, Sun SC*. RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis. Biol Reprod. 2019, 100(3):711-720.

8 Duan X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6 modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte meiosis. BBA-Mol Cell Res. 2018, 1865(2):455-462. (IF=5.3)

9 Tang F, Pan MH, Wan X, Lu Y, Zhang Y, Sun SC*. Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis. Cell Div. 2018, 13:9.

10 Liu J, Wang QC, Duan X, Cui XS, Kim NH, Zhang Y, Sun SC*. Profilin 1 plays feedback role on actin-mediated polar body extrusion in mouse oocytes. Reprod Fertil Dev. 2018, 30(5):752-58.

11 Pan MH, Wang F, Lu Y, Tang F, Duan X, Zhang Y, Xiong B, Sun SC*. FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division. J Cell Physiol. 2018, 233(3):2270-2278.

12 Duan X, Zhang Y, Chen KL, Zhang HL, Wu LL, Liu HL, Wang ZB, Sun SC*. The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis. J Cell Physiol. 2018, 233(8):6088-97.

13 Tang F, Pan MH, Lu Y, Wan X, Zhang Y, Sun SC*. Involvement of Kif4a in spindle formation and chromosome segregation in mouse oocytes. Aging Dis. 2018, 9(4):623-633.

14 Wan X, Zhang Y, Lan M, Pan MH, Tang F, Zhang HL, Ou XH*, Sun SC*. Meiotic arrest and spindle defects are associated with altered KIF11 expression in porcine oocytes. Environ Mol Mutagen. 2018, 59(9):805-812.

15 Duan X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6 modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte meiosis. BBA-Mol Cell Res. 2017: S0167-4889(17)30315-4.

16 Han J, Wang QC, Zhu CC, Liu J, Zhang Y, Cui XS, Kim NH, Sun SC*. Deoxynivalenol exposure induces autophagy/apoptosis and epigenetic modification changes during porcine oocyte maturation. Toxicol Appl Pharmacol. 2016, 300:70-76.

17 Ma R, Zhang Y, Zhang L, Han J, Rui R*. Sirt1 protects pig oocyte against in vitro aging. Anim Sci J. 2015, (9): 826-32.

18 Wang QC, Liu J, Wang ZB, Zhang Y, Duan X, Cui XS, Kim NH, Sun SC*. Dynamin 2 regulates actin-mediated spindle migration in mouse oocytes. Biol Cell. 2014,106 (6): 193-202 .

19 Duan X, Chen KL, Zhang Y, Cui XS, Kim NH, Sun SC*. ROCK inhibition prevents mouse early embryo development. Histochem Cell Biol. 2014, 142(2): 227-233.

20 Wang F, An GY, Zhang Y, Liu HL, Cui XS, Kim NH, Sun SC*. Arp2/3 complex inhibition prevents meiotic maturation in porcine oocytes. PLoS One. 2014, 9(1): e87700.