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教师目录-旧

蔡亚非

来源: 发布时间 : 2021-06-10 点击量:

   

蔡亚非

   

学历学位

研究生学历、农学博士学位

   

教授

导师类别

博士生导师

专业领域

动物遗传育种与繁殖;

研究方向

养牛学;牛遗传育种;动物生理;

教育与工作经历

19899-19937月,安徽师范大学,生物专业攻读本科

19939-19967月,安徽师范大学,动物学专业攻读硕士

20029-20057月,南京农业大学,动物遗传育种与繁殖专业攻读博士

20131-20164月,美国佐治亚医学院,生化与分子生物学系开展博士后研究工作

19967-201212月,在安徽师范大学任教

20164月至今,在南京农业大学动物科技学院任教

联系方式

ycai@njau.edu.cn13955332951

奖励及荣誉

南京农业大学高层次人才(2016);省优秀青年科技创新奖(2012);省高校优秀中青年骨干教师(2010);省首批企业科技特派员(2010);

参加学术团体及任职情况

中国养牛学会会员、美国细胞生物学会会员

承担科研项目

1、江苏省南京市玄武区奶牛DHI测定中心基础建设项目(8ZG161),  农业部畜禽良种工程基础建设项目,2016-2017  2、长三角地区生态优质高效乳业创新体系研究 [CX(17)1005]-课题一,江苏省农业科技自主创新资金项目(省财政厅),2017-2020  3、基于DHI技术建立江苏省良种奶牛数据库[ CX(18)3014]  江苏省农业科技自主创新资金项目(省财政厅),2018-2021  4、奶牛生产性能测定(DHI)技术的研发与示范推广[SXG[2016]312],江苏省农业三新工程项目,2016-2017  52016年度南京农业大学高层次人才引进项目(804090),2016-2021  6DHI标准物质中致病微生物检测(HY0039),农业部全国畜牧总站,2017-20187、利用DHI技术测定江苏地区1000头奶牛(131821301064071027),农业部全国畜牧总站,2018-2019 8牦牛良种繁育及精准饲喂技术集成与示范(2020-HZ04-B),青海省海南州科技计划项目,2019-20209青海牦牛、犏牛早期发情及妊娠快速鉴定技术研究及示范2021-HZ02-D,青海省海南州科技计划项目,2020-202110Ufm1泛素化样修饰系统E3连接酶-Ufl1缺失调控动物肝脏发育和原发性肝纤维化发生的分子机制,2020年度国家自然科学基金面上项目( 31970413),2020-202311、国家重点研发计划(2018YFC1200201PI项目:特殊生物资源(本地牛品种)特征溯源数学模型的建立,2018-2021  12Smad9基因在卵巢等级建立中的作用,2016年度国家自然科学基金面上项目( 31572265),2016-201713CIBZ基因在神经干细胞移植靶向性修复小鼠脊髓损伤中的作用,2014年度国家自然科学基金面上项目(31372207)2014-2017  

论文论著:

1. Cao Y, Li, R, Shen M. Zou Y, Jiang Q, Liu S, Lu C, Li H,  Liu H*, Cai Y*. DDRGK1, a crucial player of ufmylation  system, is indispensable for autophagic degradation by regulating lysosomal  function. Cell Death Dis. 2021 Apr 20; 12:416.

2. Quintero M, Liu S, Xia Y, Huang Y, Zou Y, Li G, Hu L, Singh  N, Blumberg R, Cai Y, Xu H, Li H. Cdk5rap3 is essential for  intestinal Paneth cell development and maintenance. Cell Death Dis.  2021 Jan 27; 12(1):131.

3. Shen Y, Zou Y, Li J, Chen F, Li H, Cai Y*.  CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat  Stress Response and Protects Mammary Epithelial Cells from Heat Injury. Int  J Mol Sci. 2020 Nov 9; 21(21):8400.

4. Cao Y, Li R, Li W, Liu H, Cai Y*. Melatonin  Attenuates Peroxynitrite-Induced Meiosis Dysfunction in Porcine  Oocytes. Reprod Sci. 2020 May; 28(5):1281-1289. 

5. Song W, Sheng L, Chen F, Tian Y, Li L, Wang G, Li H, Cai  Y*. C. sakazakii activates AIM2 pathway accompanying with  excessive ER stress response in mammalian mammary gland epithelium. Cell  Stress Chaperones. 2020 Mar; 25(2):223-233.

6. Yang F, Zhang M, Rong Y, Liu Z, Yang S, Zhang W, Li J, Cai  Y*. A Novel SNPs in Alpha-Lactalbumin Gene Effects on Lactation Traits in  Chinese Holstein Dairy Cows. Animals (Basel). 2019  Dec 29; 10(1):60.

7. Han F, Xu H, Shen JX, Pan C, Yu ZH, Chen JJ, Zhu XL, Cai  YF, Lu YP. RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation  of neuronal dendritic spine loss by paeonol in the frontal cortex of  D-galactose and aluminum‑induced Alzheimer's disease‑like rat model. Acta  Neurobiol Exp (Wars). 2020; 80(3):225-244.

8. Yang F, Chen F, Li L, Yan L, Badri T, Lv C, Yu D, Zhang M,  Jang X, Li J, Yuan L, Wang G, Li H, Li J*, Cai Y*. Three novel  playersPTK2B, SYK and TNFRSF21 were identified to be involved in the  regulation of bovine mastitis susceptibility via GWAS and post-transcriptional  analysis. Front Immunol. 2019; 10:1579.

9. Zhu H, Bhatt B, SivaprakasaS, Cai Y, Liu S,  Kodeboyina S, Patel N, Savage N, Sharma A, Kaufman R, Li H, and Singh N*.  Ufbp1 promotes plasma cell development and ER expansion by modulating  distinct branches of UPR[J]. Nature Communications, 2019;  10(1):1084.

10. Chen F, Xing C, Zhang W, Li J, Hu T, Li L, Li H*, Cai  Y*. Salubrinal, a novel inhibitor of eIF-2α dephosphorylation, promotes  erythropoiesis at early stage targeted by Ufmylation pathway [J]. J  Cell Physiol, 2019; 234(10):18560-18570.

11. Cai Yafei*, Zhu Guangxun#, Liu Siyang  , Pan Zezheng, Quintero Michaela, Poole Candace J, Lu  Chunwan, Zhu Huabin, Islam Bianca, Riggelen  Jan van, Browning Darren, Liu Kebin, Blumberg  Richard, Singh Nagendra & Li Honglin*. Indispensable  role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining  intestinal homeostasis and controlling gut inflammation. Cell  Discovery, 2019; 5:7. 

12. Chen J, Xing C, Yan L, Wang Y, Wang H, Zhang Z, Yu D, Li J,  Li H, Li J, Cai Y*. Transcriptome profiling reveals the role  of ZBTB38 knock-down in human neuroblastoma. PeerJ, 2019; 7: e6352.

13. Li J, Yue G, Ma W, Zhang  A, Zou J, Cai Y, Tang X, Wang  J, Liu J, Li H, Su H. Ufm1-Specific Ligase  Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart  Failure. Circ Heart Fail. 2018;  11(10):e004917.

14. Badri TM, Chen KL, Alsiddig MA, Li L1, Cai  Y, Wang GL. Genetic polymorphism in Hsp90AA1 gene is associated with  the thermotolerance in Chinese Holstein cows. Cell Stress  Chaperones. 2018 Jul; 23(4):639-651. 

15. Yu Daolun, Zhang Li, Wang Hejian,  Chen Fanghui, Chen Jie, Zhang Zongmeng, Li Jie,  Xing Chaofeng, Li Honglin, Li Jun, Cai Yafei*. A  potential role for SMAD9 in goose follicular selection through regulation of  mRNA levels of luteinizing hormone receptor. Theriogenology, 2019;  135 (2019): 204-212.

16. Zhang Li, Wang Hejian, Yu Daolun, Chen Jie, Xing Chaofeng,  Li Jie, Li Jun & Cai Yafei*. The effects of mouse  ovarian granulosa cell function and related gene expression by suppressing  BMP/Smad signaling pathway. Animal Cells and Systems,  2018; 22(5):317-323.

17. Chen J, Yan L, Wang H, Zhang Z, Yu  D, Xing C, Li J, Li H, Li J, Cai Y*. ZBTB38,  a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal  cord injury. Gene. 2018 Jul 31; 678:8-16.

18. Zhang Z, Chen J, Chen F, Yu D, Li  R, Lv C, Wang H, Li H, Li J, Cai Y* Tauroursodeoxycholic  acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ  gene. Cell Stress Chaperones. 2018; 23(4):551-560.

19. Zhu XL, Chen JJ, Han F, Pan C, Zhuang TT, Cai YF, Lu YP. Novel antidepressant effects  of Paeonol alleviate neuronal injury with concomitant alterations in BDNF,  Rac1 and RhoA levels in chronic unpredictable mild stress rats. Psychopharmacology  (Berl). 2018; 235(7)2177-2191. 

20. Cai Y*, Li J, Zhang Z, Chen  J, Zhu Y, Li R, Chen J, Gao L, Liu R, Teng  Y.Zbtb38 is a novel target for spinal cord injury. Oncotarget. 2017, Jul  11; 8(28):45356-45366.

 21. Li J, Wang Q,Chen F, Wang H, Chen J,Huo J and Cai  Y*. SNPs of CD14 change the mastitis morbidity of Chinese Holstein. Molecular  Medicine Reports. 2017; 16(6):9102-9110.

22. Teng Y, Cai Y, Pi W, Gao L, Shay  C. Augmentation of the anticancer activity of CYT997 in human prostate cancer  by inhibiting Src activity. J Hematol Oncol. 2017 Jun 12; 10(1):118. 

23. Miller C, Cai Y, Patton T, Graves  SH, Li H, Sabbatini ME. RCAD/BiP pathway is necessary for the  proper synthesis of digestive enzymes and secretory function of the exocrine  pancreas. Am J Physiol Gastrointest Liver Physiol. 2017  Mar 1; 312(3):G314-G326. 

24. Han F, Zhuang TT, Chen JJ, Zhu XL, Cai  YF, Lu YP. Novel derivative of Paeonol, Paeononlsilatie sodium,  alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's  disease concurrent with cofilin1/phosphorylated-cofilin1 and RAC1/CDC42  alterations in rats. PLoS One. 2017; 12(9):e0185102.

25. Cai Y, Singh N, Li H. Essential role of  Ufm1 conjugation in the hematopoietic system. Exp Hematol. 2016  Mar 24. 44(6):442-446.

26. Lu Chunwan, Makala Levi, Wu Daqing, Cai  Yafei*.  Targeting Translation: eIF4E as an Emerging  Anti-Cancer Drug Target. Expert Reviews in Molecular  Medicine, 2016; 18(e2):1-13.

27. Xie X, Tang SC, Cai Y, Pi W, Deng L, Wu G,  Chavanieu A, Teng Y. Suppression of breast cancer metastasis through the  inactivation of ADP-ribosylation factor. Oncotarget, 2016  Sep 6;7(36):58111-58120.

28. da Silva SR, Paiva SL, Bancerz M, Geletu M, Lewis AM, Chen  J, Cai Y, Lukkarila JL, Li H, Gunning PT. A selective inhibitor  of the UFM1-activating enzyme, UBA5. Bioorg Med Chem Lett,  2016; 26(18):4542-7.

29. Cai Y, Pi W, Sivaprakasam S, Zhu  X, Zhang M, Chen J, et al. UFBP1, a Key Component of the Ufm1 Conjugation  System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development. PLoS  Genet, 2015; 11(11): e1005643.

30. Huang Pin, Lu Chunwan #, Li Jun ,Xu Jun, Liu Zaiqun, Wang  Qiang, Wang Zhao, HuoJiayan, Li Honglin, Teng Yong, Cai Yafei*.  Mutations in HSP70-2 gene change the susceptibility to clinical mastitis in  Chinese Holstein. Gene, 2015; 559(1):62-72.

31. Xu Jun, Li Jun #, Wang Haosen #, Wang Guanglin #, Chen Jie,  Huang Pin, Cheng Jienan, Gan Lu, Wang Zhao & Cai Yafei*. A  novel SMAD family protein, SMAD9 is involved in follicular initiation and  changes egg yield of geese via synonymous mutations in exon1 and  intron2. Mol Biol Rep, 2015; 42:289-302.

32. Zhang M, Zhu X, Zhang Y, Cai Y, Chen J,  Sivaprakasam S, Gurav A, Pi W, Makala L, Wu J, Pace B, Tuan-Lo D, Ganapathy  V, Singh N, Li H. RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic  stem cell function and murine hematopoiesis. Cell Death Differ,  2015 May 8; 22(12):1922-34.

33. Cai Yafei, Li Jun, Yang Shiyong, Li Ping, Zhang Xuan,  Liu Honglin*. CIBZ, a novel BTB domain-containing protein, is involved in mouse  spinal cord injury via mitochondrial pathway independent of p53 gene. PLoS  ONE, 2012; 7(3): e33156.

34. Cheng Jienan, Li Jun, Zhang Wenxin, Cai Yafei*,  Wang Genlin. Mutations in lipopolysaccharide-binding protein (LBP) gene  change the susceptibility to clinical mastitis in Chinese Holstein. Molecular  Biology Reports, 2012; 39(10): 9601-9612.

35. Yang Fan, Li Lian, Liu Huiling, Cai Yafei*, Wang  Genlin. Polymorphism in the exon 4 of β-lactoglobulin variant  B precursor gene and its association with milk traits and protein structure  in Chinese Holstein. Molecular Biology Reports,2012;  29(4): 3957-3964.

36. Chen Jie, Liu Huiling,Cai Yafei*, Wang Genlin, Liu  Honglin, Li Jing.Mutations in the exon 10 of Prolactin receptor gene (PRLR)  change the egg production performance in Wanjiang White Goose. Molecular  Biology Reports, 2012; 39(1): 475-483.

37. Cai Ya-Fei*, Fan Rui, Hua Tian-Miao, Liu Hui-Ling, Li  Jing. Nimodipine alleviates apoptosis-mediated impairments through  mitochondrial pathway after spinal cord injury. Current Zoology,  2011; 57(3):340-349.

38. Chen Jie, Wang Genlin, Cai Yafei*. High Mutation  Rate in PRL Intron 2 Regulates the Egg-laying Performance in the Two-line  Hybrid Wanjiang White Goose, Journal of Applied Animal Research, 2011;  39(3):175-180.

39. Liu Huiling, Li Jing, Yang Fan, Cai Yafei*.  Molecular Sexing of Endangered Cranes Based on CHD-W gene. Journal  of Applied Animal Research, 2011; 39(3): 212-217.

40. Liu Qinghua, Wang Yan, Cai Yafei*, Liu Huiling,  Chen Jie, Li Ping, Cheng Jienan, Liu Honglin. T Lymphocyte Selection is  Indispensible for the Development of Goose Bursa of Fabricius. Current  Research in Poultry Science, 2011; 1(2):37-53.

41. Xu Shiyong, Sun Yan, Ding Hongmei, Wang Meng, Cai  Yafei*, Chen Jie, Liu Honglin. Efficient production of transgenic  chickens using self-inactive HIV-based lentiviral vectors. Current  Zoology, 2009; 55(5):383-387.

42. Cai Yafei, Liu Qinghua, Xing Guangdong, Wang Genlin.  Polymorphism of the promoter region of hsp70 gene and its relationship with  the expression of HSP70mRNA, HSF1mRNA, Bcl-2mRNA and Bax-αmRNA in lymphocytes  in peripheral blood of heat shock dairy cows. Asian-Australasian  Journal of Animal Science, 2005; 18(5): 734-740.

 

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