张昊

性    别

男

学历学位

研究生学历、农学博士学位

职    称

副教授

导师类别

硕士生导师

专业领域

动物营养与饲料科学

研究方向

动物营养生理及调控；饲料添加剂的开发与应用

教育与工作经历

2007年9月-2011年6月， 山东农业大学，动物科学专业攻读本科

2011年9月-2017年6月， 南京农业大学，动物营养与饲料科学专业攻读博士

2017年12月-2021年8月，南京农业大学，动物科技学院，师资博士后

2021年9月至今，        南京农业大学，动物科技学院，任教

联系方式

zhanghao89135@163.com；h.zhang@njau.edu.cn

奖励及荣誉

1. 2018年度中国畜牧兽医学会动物营养学分会帝斯曼缤纷科技奖-中国青年学者动物营养科学奖

2. 2018年度南京农业大学优秀博士论文

3. 2017年度南京农业大学优秀博士毕业生

4. 2017年度南京农业大学博士生校长奖学金

参加学术团体及任职情况

江苏省饲料工业协会副秘书长

承担科研项目

1. 国家自然科学基金面上项目(32272917)，3’-羟基紫檀芪脂质体调节整合应激反应改善IUGR猪肝脏糖脂代谢的机制，主持，2023-2026；

2. 江苏省农业科技自主创新资金二类项目(CX(22)2019)，提升仔猪肠道免疫机能的微生态调控关键技术研发，任务负责人，2022-2025；

3. 国家自然科学基金青年科学基金项目(31802094)，从SIRT1-内质网应激调节途径探讨紫檀芪缓解IUGR断奶仔猪肝脏损伤的机理，主持，2019-2021；

4. 中国博士后科学基金第12批特别资助(2019T120436)，内质网功能重塑对IUGR仔猪肝损伤的保护作用及营养干预，主持，2019-2021；

5. 江苏省基础研究计划项目青年项目(BK20180531)，基于SIRT3研究白藜芦醇苷改善IUGR断奶仔猪肠道损伤与线粒体功能紊乱的机制，主持，2018-2021；

6. 中国博士后科学基金第63批面上项目(2018M632320)，从SIRT3-线粒体途径探讨虎杖苷保护IUGR仔猪肠道的机制，主持，2018-2020；

7. 中央高校基本科研业务费(KJQN201934)，主持，2019-2020；

8. 上海市兽医生物技术重点实验室开放课题(klab201710)，白藜芦醇类植物源活性物质改善IUGR新生仔猪肝脏损伤和氧化应激的机制研究，主持，2017-2019。

论文论著：

围绕动物生产中常见的应激现象，在生理学和分子水平探索细胞器应激、肝肠损伤与代谢紊乱的机制关联，以开发具有高靶向性的新植提饲料添加剂。近年来以第一或通讯作者(含共同)发表研究性论文如下：

1. Yanan Chen, Yue Li, Peilu Jia, Shuli Ji, Hao Zhang (通讯), Tian Wang. Polydatin attenuates intra-uterine growth retardation-induced liver injury and mitochondrial dysfunction in weanling piglets by improving energy metabolism and redox balance. Antioxidants, 2022, 11, 666.

2. Yanan Chen, Hao Zhang (共同通讯), Yue Li, Shuli Ji, Peilu Jia, Tian Wang (共同通讯). Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy. Journal of Animal Science and Biotechnology, 2022, 13, 125.

3. Yanan Chen, Hao Zhang (共同通讯), Yue Li, Shuli Ji, Peilu Jia, Tian Wang (共同通讯). Pterostilbene prevents tunicamycin-induced intestinal barrier damage by targeting endoplasmic reticulum stress, oxidative stress, autophagy, and gut microbiota. Journal of Agricultural and Food Chemistry, 2022, 70, 13661-13675.

4. Yanan Chen, Hao Zhang (共同通讯), Yue Li, Tian Wang (共同通讯). Pterostilbene confers protection against diquat-induced intestinal damage with potential regulation of redox status and ferroptosis in broiler chickens. Oxidative Medicine and Cellular Longevity, 2023, 2023, 8258354.

5. Hao Zhang, Yanan Chen, Yueping Chen, et al. Pterostilbene attenuates liver injury and oxidative stress in intrauterine growth-retarded weanling piglets. Nutrition, 2021, 81, 110940.

6. Hao Zhang, Yanan Chen, Yueping Chen, et al. Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets. Journal of Animal Science and Biotechnology, 2020, 11, 52.

7. Hao Zhang, Yanan Chen, Yue Li, et al. Protective effect of polydatin on jejunal mucosal integrity, redox status, inflammatory response, and mitochondrial function in intrauterine growth-retarded weanling piglets. Oxidative Medicine and Cellular Longevity, 2020, 2020, 7178123.

8. Hao Zhang, Yanan Chen, Yueping Chen, et al. Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat. Food & Function, 2020, 11, 4202–4215.

9. Hao Zhang, Yanan Chen, Yue Li, et al. Protective effects of pterostilbene against hepatic damage, redox imbalance, mitochondrial dysfunction, and endoplasmic reticulum stress in weanling piglets. Journal of Animal Science, 2020, 98(10), skaa328.

10. Hao Zhang, Yanan Chen, Yueping Chen, et al. Dietary pterostilbene supplementation attenuates intestinal damage and immunological stress of broiler chickens challenged with lipopolysaccharide. Journal of Animal Science, 2020, 98(1), skz373.

11. Hao Zhang, Yue Li, Yueping Chen, et al. N-Acetylcysteine protects against intrauterine growth retardation-induced intestinal injury via restoring redox status and mitochondrial function in neonatal piglets. European Journal of Nutrition, 2019, 58, 3335–3347.

12. Hao Zhang, Yueping Chen, Yue Li, et al. L-Threonine improves intestinal mucin synthesis and immune function of intrauterine growth-retarded weanling piglets. Nutrition, 2019, 59, 182–187.

13. Hao Zhang, Yue Li, Yueping Chen, et al. Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra-uterine growth-retarded suckling piglets. Journal of Animal Physiology and Animal Nutrition, 2019, 103, 868–881.

14. Hao Zhang, Weipeng Su, Zhixiong Ying, et al. N‑acetylcysteine attenuates intrauterine growth retardation‑induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis. European Journal of Nutrition, 2018, 57, 327–338.

15. Hao Zhang, Yue Li, Weipeng Su, et al. Resveratrol attenuates mitochondrial dysfunction in the liver of intrauterine growth retarded suckling piglets by improving mitochondrial biogenesis and redox status. Molecular Nutrition and Food Research, 2017, 61, 1600653.

16. Hao Zhang, Yue Li, Xiang Hou, et al. Medium-chain TAG improve energy metabolism and mitochondrial biogenesis in the liver of intra-uterine growth-retarded and normal-birth-weight weanling piglets. British Journal of Nutrition, 2016, 115, 1521–1530.

17. Hao Zhang, Yue Li, Tian Wang. Antioxidant capacity and concentration of redox-active trace mineral in fully weaned intra-uterine growth retardation piglets. Journal of Animal Science and Biotechnology, 2015, 6, 48.

18. Hao Zhang, Yueping Chen, Yue Li, et al. Medium-chain TAG attenuate hepatic oxidative damage in intra-uterine growth-retarded weanling piglets by improving the metabolic efficiency of the glutathione redox cycle. British Journal of Nutrition, 2014, 112: 876–885.