苗义龙

性    别

男

学历学位

农学博士学位

职    称

副研究员

导师类别

硕士生导师

专业领域

动物繁殖学

研究方向

动物生殖生物学

教育与工作经历

2010年9月-2013年6月，山东农业大学，动物遗传育种与繁殖专业攻读硕士

2015年9月-2018年6月，南京农业大学，动物遗传育种与繁殖专业攻读博士

2018年12月-2022年6月，南京农业大学，动物繁殖学，师资博士后

2022年9月至今，南京农业大学，动物繁殖学，副研究员

联系方式

miaoyilong@njau.edu.cn

奖励及荣誉

第四届（2021年）妇幼健康科学技术奖自然科学奖一等奖

参加学术团体及任职情况

《农业生物技术学报》第四届编辑委员会青年委员

江苏省研究型医院学会生殖医学专业委员会常务委员

江苏省抗衰老学会健康促进分会委员

承担科研项目

国家重点研发计划青年科学家项目，，基于胚胎工程的猪基因组选择

新技术创建与效果评估，项目骨干。

国家自然基金青年科学基金项目，31900592，Nipbl调控小鼠卵母细胞减数分裂成熟中的作用及机制研究，主持。

江苏省自然基金青年项目，BK20190526，Nipped-B-like蛋白在卵母细胞发育中的作用机理研究，主持。

第65批中国博士后科学基金面上资助，2019M651849，乙二醇醚暴露对卵母细胞质量及后代生殖力的影响研究，主持。

中央高校基本科研业务费专项资金资助，KJQN202037, Nipbl调控小鼠卵母细胞减数分裂成熟中的作用及机制研究，主持。

横向课题，牛核移植胚胎制备技术服务，主持。

论文论著：

代表作：

Miao Yilong, Cui Zhaokang, Gao Qian, Rui Rong, Xiong Bo*; Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes, Cell Reports, 2020, 32(5): 107987. (IF=9.423; IF_5-2021 =10.394, TOP20，30/195，JCR Q1)

Miao Yilong#, Wang Pan#, Xie Bingteng#, Yang Mo, Li Sen, Cui Zhaokang, Fan Yong*, Li Mo*, Xiong Bo*; BRCA2 deficiency is a potential driver for human primary ovarian insufficiency, Cell Death & Disease, 2019, 10: 474. (IF=8.469; IF_5-2021 =8.713, TOP20，30/195，JCR Q1)

Miao Yilong, Zhou Changyin, Bai Qingyun, Cui Zhaokang, ShiYang Xiayan, Lu Yajuan, Zhang Mianqun, Dai Xiaoxin, Xiong Bo*; The protective role of melatonin in porcine oocyte meiotic failure caused by the exposure to benzo(a)pyrene, Human Reproduction, 2018, 33(1): 116-127. (IF=6.918; IF_5-2021 =7.366, TOP20，30/195，JCR Q1)

Miao Yilong, Zhou Changyin, Cui Zhaokang, Zhang Mianqun, ShiYang Xiayan, Lu Yajuan, Xiong Bo*; Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress, FASEB Journal, 2018, 32(3): 1328-1337. (IF=5.191; IF_5-2021 =5.955, TOP20，30/195，JCR Q1

Zhaokang Cui#, Yajuan Lu#, Yilong Miao#, Xiaoxin Dai, Yu Zhang and Bo Xiong* ;Transglutaminase 2 crosslinks zona pellucida glycoprotein 3 to prevent polyspermy, Cell Death & Differentiation, 2022 Jan 11. (IF= 15.828; IF_5-2021 =12.774, TOP20，11/297，JCR Q1) 

第一/通讯作者（含共同）论文：

2022年

Meijie Song, Yu Li, Yihang Zhou, Jiner Yan, Xiaohua Zhou, Qian Gao, Yilong Miao*, Bo Xiong*. Nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stress. Journal of Animal Science and Biotechnology. 2022 Jun 15;13(1):68. (IF= 6.175; IF_5-2021 =6.853, TOP20，59/195，JCR Q1).

Yilong Miao1^†, Zhaokang Cui1^†, Xiaotong Zhu¹, Qian Gao², and Bo Xiong¹; Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes, Journal of Molecular Cell Biology, 2022 Apr 19;mjac025. (IF= 6.216; IF_5-2021 =6.688, TOP20，59/195，JCR Q2)

Zhaokang Cui#, Yajuan Lu#, Yilong Miao#, Xiaoxin Dai, Yu Zhang and Bo Xiong* ;Transglutaminase 2 crosslinks zona pellucida glycoprotein 3 to prevent polyspermy, Cell Death & Differentiation, 2022 Jan 11. (IF= 15.828; IF_5-2021 =12.774, TOP20，11/297，JCR Q1) 

2021年

Chen Ying , Pan Chen, Lu Yajuan, Miao Yilong*, Xiong Bo *; HDAC8 drives spindle organization during meiotic maturation of porcine oocytes, Cell Proliferation, 2021 Aug 25; e13119. (IF= 6.831; IF_5-2021 =6.154, TOP20，30/195，JCR Q1)

Chen Jingyue #, Miao Yilong #, Gao Qian, Cui Zhaokang, Xiong Bo *; Exposure to perfluorooctane sulfonate in vitro perturbs the quality of porcine oocytes via induction of apoptosis, Environmental Pollution, 2021 Sep 1;284:117508. (IF= 8.071; IF_5-2021 =8.350, TOP20，30/195，JCR Q1)

Chen Jingyue, Cui Zhaokang, Qiu Yawei, Zhang Xingxing, Chen Fang, Wang Huili, Xiong Bo, Miao Yilong *, Gao Qian *; Exposure to Copper Compromises the Maturational Competency of Porcine Oocytes by Impairing Mitochondrial Function, Frontiers in Cell and Developmental Biology, 2021 Jun 4;9:678665. (IF= 6.684; IF_5-2021 =7.219, TOP20，30/195，JCR Q1)

Miao Yilong#, Li Xinyu#, Shi Xiaoyan, Gao Qian, Chen Jingyue, Wang Rui, Fan Yong*, Xiong Bo*; Nicotinamide mononucleotide restores the meiotic competency of porcine oocytes exposed to ethylene glycol butyl ether, Frontiers in Cell and Developmental Biology, 2021, 9: 628580. (IF=6.684; IF_5-2021 =7.219, TOP20，30/195，JCR Q1)

Miao Yilong#, Chen Jingyue#, Gao Qian, Xiong Bo*, Generation and assessment of high-quality mouse oocytes and embryos following nicotinamide mononucleotide administration, STAR Protocols, 2021, 2(1): 100298.

2020年

Miao Yilong, Cui Zhaokang, Gao Qian, Rui Rong, Xiong Bo*; Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes, Cell Reports, 2020, 32(5): 107987. (IF=9.423; IF_5-2021 =10.394, TOP20，30/195，JCR Q1)

2019年

Miao Yilong#, Wang Pan#, Xie Bingteng#, Yang Mo, Li Sen, Cui Zhaokang, Fan Yong*, Li Mo*, Xiong Bo*; BRCA2 deficiency is a potential driver for human primary ovarian insufficiency, Cell Death & Disease, 2019, 10: 474. (IF=8.469; IF_5-2021 =8.713, TOP20，30/195，JCR Q1)

2018年

Miao Yilong, Zhou Changyin, Bai Qingyun, Cui Zhaokang, ShiYang Xiayan, Lu Yajuan, Zhang Mianqun, Dai Xiaoxin, Xiong Bo*; The protective role of melatonin in porcine oocyte meiotic failure caused by the exposure to benzo(a)pyrene, Human Reproduction, 2018, 33(1): 116-127. (IF=5.733; IF_5-2019 =5.818, TOP20，30/195，JCR Q1)

Miao Yilong, Zhou Changyin, Cui Zhaokang, Zhang Mianqun, ShiYang Xiayan, Lu Yajuan, Xiong Bo*; Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress, FASEB Journal, 2018, 32(3): 1328-1337. (IF=4.966; IF_5-2019 =5.394, TOP20，30/195，JCR Q1)

2017年

Miao, Yilong#; Zhou, Changyin#; Cui, Zhaokang#; Tang, Liansheng; ShiYang, Xiayan; Lu, Yajuan; Zhang, Mianqun; Dai, Xiaoxin; Xiong, Bo*; Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement, Cell Cycle, 2017, 16(21): 2139-2145. (IF=3.259; IF_5-2018 =3.527, TOP20，30/195，JCR Q1)

Miao, Yilong; Zhou, Changyin; Cui, Zhaokang; Dai, Xiaoxin; Zhang, Mianqun; Lu, Yajuan; Xiong, Bo*; Smc1beta is required for activation of SAC during mouse oocyte meiosis, Cell Cycle, 2017, 16(6): 536-544. (IF=3.259; IF_5-2018 =3.527, TOP20，30/195，JCR Q1)

2015年

Gong Shai#; Miao, Yilong#, Jinghe Tan* et al. Dynamics and Correlation of Serum Cortisol and Corticosterone under Different Physiological or Stressful Conditions in Mice[J]. Plos One, 2015, 10(2): e0117503. (IF=2.806; IF_5-2016 =3.394, TOP20，30/195，JCR Q1)

其他参与发表论文：

2023年

Li Y, Xiong B, Yilong Miao, Gao Q.*，Silibinin supplementation ameliorates the toxic effects of butyl benzyl phthalate on porcine oocytes by eliminating oxidative stress and autophagy. Environmental Pollution. 2023 Jul 15; 329:121734.

Wang R, Chen J, Cui Z, Li Y, Gao Q, Yilong Miao, Wang H*, Xiong B*. Exposure to diisononyl phthalate deteriorates the quality of porcine oocytes by inducing the apoptosis. Ecotoxicology and Environmental Safety. 2023 Apr 1; 254:114768.

Chen J, Wang R, Liu C, Xiong B, Yilong Miao, Rao C, Sun H, Gao Q, Xu B*. Velvet antler water extract protects porcine oocytes from lipopolysaccharide-induced meiotic defects. Cell Proliferation, 2023 Jan 3; e13392.

2021年

Changyin Zhou, Xue Zhang, Yilong Miao, Yu Zhang, Yu Li, Bo Xiong*；The cohesin stabilizer Sororin drives G 2 -M transition and spindle assembly in mammalian oocytes, Science Advances, 2021 Sep 24;7(39):eabg9335.

Shi, Xiaoyan; Miao, Yilong; Zhang, Kemei; Gong, Shuai; Xiong, Bo*; Ethylene glycol butyl ether deteriorates oocyte quality via impairing mitochondrial function, The FASEB Journal, 2021 Apr;35(4):e21280.

Pan Wang, Yilong Miao, Xiao-Han Li, Na Zhang, Qilong Wang, Wei Yue, Shao-Chen Sun, Bo Xiong^*, Jie Qiao & Mo Li*; Proteome landscape and spatial map of mouse primordial germ cells, Science China Life Sciences, 2021 Jun;64(6):966-981.

2020年

Zhou, Changyin; Miao, Yilong; Cui, Zhaokang; ShiYang, Xiayan; Zhang, Yu; Xiong, Bo*; The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I, Science Advances, 2020, 6(15): eaax3969.

ShiYang Xiayan; Miao Yilong; Cui Zhaokang; Lu Yajuan; Zhou Changyin; Zhang Yu; Xiong Bo*; Casein kinase 2 modulates the spindle assembly checkpoint to orchestrate porcine oocyte meiotic progression, Journal of Animal Science and Biotechnology, 2020, 11(1): 31.

2019年

Zhang, Mianqun#; ShiYang, Xiayan#; Zhang, Yuwei; Miao, Yilong; Chen,Ying; Cui, Zhaokang; Xiong, Bo*; Coenzyme Q10 ameliorates the quality of postovulatory aged oocytes by suppressing DNA damage and apoptosis , Free Radical Biology and Medicine, 2019 Nov 1;143:84-94.

2018年

Lu, Yajuan; Li, Sen; Cui, Zhaokang; Dai, Xiaoxin; Zhang, Mianqun; Miao, Yilong; Zhou, Changyin; Ou, Xianghong; Xiong, Bo*; The cohesion establishment factor Esco1 acetylates alpha-tubulin to ensure proper spindle assembly in oocyte meiosis, Nucleic Acids Research, 2018, 46(5): 2335-2346.

Zhang, Mianqun; Miao, Yilong; Chen, Qian; Cai, Meng; Dong, Wenkang; Dai, Xiaoxin; Lu, Yajuan; Zhou, Changyin; Cui, Zhaokang; Xiong, Bo*; BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility, The FASEB Journal, 2018, 32(1): 342-352.

2017年

Lu, Yajuan; Dai, Xiaoxin; Zhang, Mianqun; Miao, Yilong; Zhou, Changyin; Cui, Zhaokang; Xiong, Bo*; Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis, Nucleic Acids Research, 2017, 45(16): 9388-9397.

Zhang, Mianqun; Dai, Xiaoxin; Lu, Yajuan; Miao, Yilong; Zhou, Changyin; Cui, Zhaokang; Liu, Honglin; Xiong, Bo*; Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse, Journal of Pineal Research, 2017, 62(3): e12396.