于敏莉

性    别

女

学历学位

研究生学历、农学博士学位

职    称

副教授

导师类别

硕士生导师

专业领域

动物遗传育种与繁殖

研究方向

家禽生殖细胞发育；肌肉发育及肉质调控；家禽生产

教育与工作经历

2003年9月-2007年6月，东北农业大学，动物科学专业攻读本科

2007年9月-2012年6月，浙江大学，动物遗传育种与繁殖专业攻读博士

2012年6月至今，在南京农业大学动物科技学院任教

2016年12月-2017年12月，康奈尔大学，访问学者

联系方式

yuminli@njau.edu.cn；025-84395036

奖励及荣誉

1.南京农业大学青年教师教学竞赛二等奖，2022

2.南京农业大学微课教学比赛三等奖，2022

3.动科院青年教师授课比赛一等奖，2022

4.南京农业大学教师教学质量评价优秀，2021-2022学年

5.南京农业大学动物科技学院优秀党务工作者，2021

6.南京农业大学教师教学比赛（教师教学创新组）优秀奖，2020

7.动科院青年教师授课比赛特等奖，2020

8.南京农业大学教师教学质量评价优秀，2018-2019第一、二学期

9.动科院青年教师授课比赛一等奖，2018

10.动科院青年教师授课比赛二等奖，2016

11.温氏奖教金，2015

参加学术团体及任职情况

中国畜牧兽医学会动物生理生化分会，家禽分会，遗传分会会员

承担科研项目

主持项目：1.国家自然科学基金面上项目，2024-2027；2.中央高校基本科研业务费科普专项，2023；3.横向课题，2021-2022；4.教改项目3项2020,2021,2022；5.中央高校基本科研业务费项目, 2017-2019；6.国家自然科学基金青年基金,2015-2017； 7.江苏省科技计划项目(苏北科技发展计划——科技富民强县项目)；8.2014-2016；江苏省自然科学基金项目,2013-2015；9.校青年科技创新基金项目2012-2013；

主要参与项目：国家科技支撑计划项目、国家重点研发计划、国家自然科学基金青年基金项目、面上项目、江苏省种业振兴揭榜挂帅项目、江苏省农业科技自主创新资金等。

参编普通高等教育“十四五”规划教材《Modern Animal Reproductive Technology》和“新农科”规划教材《畜牧学概论》。

论文论著：

1.Heng Cao, Yinglin Lu, Xingyu Zhang, Jing Zhou, Fan Li, Zaixu Pan, Shanjin Xu and Minli Yu*. Effects of antibacterial peptide microcin J25 on growth performance, antioxidant capacity, intestinal barrier function and intestinal microbiota in pigeon squabs. Italian Journal of Animal Science. 2024, 23 (1):427-439.

2.Yinglin Lu, Ming Li, Heng Cao, Jing Zhou, Fan Li, Debing Yu and Minli Yu*. Ten-eleven translocation 1 mediating DNA demethylation regulates the proliferation of chicken primordial germ cells through the activation of Wnt4/β-catenin signaling pathway. Animal Bioscience. 2024, 37(3):471-480.

3.Yuchen Zhang, Yinglin Lu, Minli Yu, Jin Wang, Xubin Du, Dong Zhao, Huifang Pian, Zongliang He, Guansuo Wu, Shiwei Li, Sike Wang, Debing Yu*. Transcriptome Profiling Identifies Differentially Expressed Genes in Skeletal Muscle Development in Native Chinese Ducks. Genes (Basel). 2024, 28; 15(1):52. 

4.Fan Li^#, Zongliang He^#, Yinglin Lu, Jing Zhou, Heng Cao, Xingyu Zhang, Hongjie Ji, Kunpeng Lv, Debing Yu* and Minli Yu*. Identification of relevant differential genes to the di-vergent development of pectoral muscle in ducks by transcriptomic analysis. Animal Bioscience. 2024, Accepted.

5.Yinglin Lu^#, Jing Zhou^#, Fan Li, Heng Cao, Xingyu Zhang, Debing Yu, Zongliang He, Hongjie Ji, Kunpeng Lv, Guansuo Wu, Minli Yu*. The Integration of Genome-Wide DNA Methylation and Transcriptomics Identifies the Potential Genes That Regulate the Development of Skeletal Muscles in Ducks. International Journal of Molecular Sciences. 2023, 24(20):15476.

6.Dongfeng Li, Yongfu Wu, Kai Shi, Minghui Shao, Ying Duan, Minli Yu, Chungang Feng*. Untargeted metabolomics reveals the effect of rearing systems on bone quality parameters in chickens. Front Genet. 2023, 13:1071562.

7.Yinglin Lu, Kai Shi, Haobin Wang, Heng Cao, Fan Li, Jing Zhou, Minli Yu*and Debing Yu*. Knockdown of Tet2 inhibits the myogenic differentiation of chicken myoblasts induced by Ascorbic acid. International Journal of Molecular Sciences.2022, 23: 13758.

8.Yinglin Lu, Haobin Wang, Heng Cao, Xiaolu Chen, Dongfeng Li, Debing Yu and Minli Yu *. Ascorbic acid and all-trans retinoic acid promote proliferation of chicken embryonic stem cells by mediating DNA demethylation. In Vitro Cellular & Developmental Biology. 2022, 58(3):199-209.

9.Minghui Shao, Kai Shi , Qian Zhao, Ying Duan, Yangyang Shen, Jinjie Tian, Kun He, Dongfeng Li, Minli Yu, Yangqing Lu, Yanfei Tang, Chungang Feng*. Transcriptome Analysis Reveals the Differentially Expressed Genes Associated with Growth in Guangxi Partridge Chickens. Genes (Basel). 2022, 13(5):798.

10.Kai Shi, Yinglin Lu, Xiaolu Chen, Dongfeng Li, Wenxing Du and Minli Yu*. Effects of Ten-Eleven Translocation-2 (Tet2) on myogenic differentiation of chicken myoblasts. Comparative Biochemistry and Physiology, Part B. 2021, 252:110540.

11.Dongfeng Li, Qin Wang, Kai Shi, Yinglin Lu, Debing Yu, Xiaoli Shi, Wenxing Du and Minli Yu*. Testosterone promotes the proliferation of chicken embryonic myoblasts via androgen receptor and PI3K/Akt signaling pathway. International Journal of Molecular Sciences.  2020, 21(3): e1152.

12.Mengjie Liu, Yinglin Lu, Peng Gao, Xiaolei Xie, Dongfeng Li, Debing Yu* and Minli Yu*. Effect of curcumin on laying performance, egg quality, endocrine hormones, and immune activity in heat-stressed hens. Poultry Science. 2020, 99(4):2196-2202.

13.Li Dongfeng, Pan Zaixu, Zhang Kun, Yu Minli, Yu Debing, Lu Yinglin, Wang Jiantao, Zhang Jin, Zhang Kangning, Du Wenxing*. Identification of the differentially expressed genes of muscle growth and intramuscular fat metabolism in the development stage of yellow broilers, Genes, 2020, 11(3): E244.

14.Li Dongfeng, Zhang Kun, Pan Zaixu, Yu Minli, Lu Yinglin, Wang Guiying, Wu Junfeng, Zhang Jin, Zhang Kangning, Du Wenxing*. Antibiotics promote abdominal fat accumulation in broilers, Animal Science Journal, 2020, 91(1): e13326. 

15.Minli Yu*, Dongfeng Li, Wanyan Cao, Xiaolu Chen, and Wenxing Du*. Effects of TET1 on DNA methylation and gene expression in chicken primordial germ cells, Reprod Fertil Dev, 2019, 31(3): 509-520.

16.Minli Yu*, Yali Xu, Ming Li, Dongfeng Li, Yinglin Lu, Debing Yu, and Wenxing Du*. Bisphenol A accelerates meiotic progression in embryonic chickens via the estrogen receptor β signaling pathway. Gen Comp Endocr, 2018, 259:66-75.

17.Minli Yu*, Huan Wang, Liu Zhen, Yinglin Lu, Debing Yu, Dongfeng Li and Wenxing Du*. Ebp1 regulates myogenic differentiation of myoblast cells via SMAD2/3 signaling pathway. Dev Growth Differ, 2017, 59(6):540-551.

18.Xiaochuan Tang, Shiyong Xu, Hongpeng Zhang, Qing Chen, Rongyang Li, Wangjun Wu, Minli Yu and Honglin Liu*. Retinoic acid promotes expression of germline-specific genes in chicken blastoderm cells by stimulating Smad1/5 phosphorylation in a feeder-free culture system. BMC Biotechnol, 2017, 17(1):17.

19.Minli Yu, Huan Wang, Yali Xu, Debing Yu, Dongfeng Li, Xiuhong Liu and Wenxing Du*. Insulin-like growth factor-1 (IGF-1) promotes myoblast proliferation and skeletal muscle growth of embryonic chickens via the PI3K/Akt signalling pathway. Cell Biol Int, 2015, 39(8):910-922

20.Minli Yu, Yali Xu, Defu Yu, Debing Yu*, Wenxing Du*. Comparative analysis of temporal gene expression patterns in the developing ovary of the embryonic chicken. J Reprod Develop, 2015, 61(2): 123-133

21.Debing Yu^#*, Minli Yu ^#, Fei Lin, Baochun Jiang, Lina Yang, Siyu Wang, Ying Zhao, Zhengchao Wang. Morphological and hormonal identification of porcine atretic follicles and relationship analysis of hormone receptor levels during granulosa cell apoptosis in vivo. J Integr Agr, 2014, 13(5):1058-1064（Co-first author）

22.Minli Yu, Ping Yu, Imdad Hussain Leghari, Chutian Ge, Yuling Mi, Caiqiao Zhang*. Raldh2, the enzyme for retinoic acid synthesis, mediates meiosis initiation in germ cells of the female embryonic chickens. Amino Acids, 2013, 44(2):405-412

23.Minli Yu，Chutian Ge，Yuling Mi, Caiqiao Zhang*. Retinoic acid promotes proliferation of chicken primordial germ cells via activation of PI3K/Akt-mediated NF-κB signaling cascade. Cell Biol Int, 2012, 36(8):705-712

24.Minli Yu, Kun Guan, Caiqiao Zhang*. The promoting effect of retinoic acid on proliferation of chicken primordial germ cells by increased expression of cadherin and catenins. Amino Acids, 2011, 40(3):933-941

25.Chutian Ge, Minli Yu, Caiqiao Zhang*. GPR30 mediates estrogen-induced proliferation of primordial germ cells via EGFR/Akt/β-catenin signaling pathway in chickens. Endocrinology, 2013, 153(7):3504-3516

26.Chutian Ge, Minli Yu, James N Petitte, Caiqiao Zhang*. Epidermal growth factor promotes proliferation of chicken primordial germ cells: Involvement of Ca²⁺/PKC and NF-κB. Biol Reprod,2009, 80: 528-536

27.Xu Yulin, Yu Minli, Wu Fabai, Jianguo Sun, Chris Wood, Masa-Aki Hattori, Jinfu Wang*, Yongmei Xi*. Effects of ectopic expression of human telomerase reverse transcriptase on immortalization of feather keratinocyte stem cells. J Exp Zool B Mol Dev Evol,2009, 312B 8: 872-884

28.李东锋，葛建雅，王浩彬，何宗亮，金通，于敏莉*. 北京鸭、连城白鸭及其杂交F5资源群体骨骼肌发育差异的研究. 南京农业大学学报, 2022,45(6):1235-1245.

29.李雪花，刘震，杜文兴，于敏莉*. 萨索鸡与AA 肉鸡肌肉脂肪酸组成的比较. 畜牧与兽医，2022，54(5):19-25.

30.王琴，刘震，史凯，杜文兴，于敏莉*.萨索鸡与白羽鸡及其杂交F1代生长和屠宰性能比较研究. 畜牧与兽医，2018，50 (12) : 1-6.

31.于敏莉, 李铭, 虞德兵, 杜文兴*. 激活素A通过TGFβ/SMAD信号通路促进鸡原始生殖细胞增殖. 农业生物技术学报, 2017, 25(4): 537-546.

32.徐雅丽, 王欢, 刘震, 杜文兴, 于敏莉*. 不同品种鸡蛋品质及孵化期发育变化的比较研究. 畜牧与兽医，2017，49 (1) : 12-15.

33.解晓东, 虞德兵, 于敏莉, 林凯, 何宗亮, 杜文兴*. siRNA干扰Wnt11对鸭成肌细胞增殖的影响. 畜牧与兽医, 2017, 49 (2): 42-46.

34.刘震, 于敏莉, 王欢, 李东峰, 杜文兴*. 萨索鸡、涟水土鸡及其杂交F1代生长曲线的拟合分析. 畜牧与兽医, 2017, 49 (5): 8-12.

35.张琨, 卞良勇, 许盛海, 文媛, 张进, 张康宁, 虞德兵, 陆应林, 于敏莉, 杜文兴, 李东锋*. 基于L、a、b色度系统的乌骨鸡肤色规律研究. 中国家禽, 2017,15：12-16.

36.李 铭, 李东锋, 杜文兴, 于敏莉^*.TET蛋白质在动物原始生殖细胞发育过程中的作用.中国细胞生物学学报，2016, 38(8), 1043-1048.

37.潘磊庆，张伟，于敏莉，孙晔，顾欣哲，马龙，李紫君，胡鹏程，屠康*.基于高光谱图像的鸡种蛋孵化早期胚胎性别鉴定. 农业工程学报，2016，32(2),181-186.

38.林凯，虞德兵，解晓东，于敏莉，李东锋，杜文兴. TGF-β/Smad信号通路在Follistatin调节鸭骨骼肌卫星细胞增殖过程中的作用机制. 中国农业科学，2015，48(12):2460-2468.