性    别

女

学历学位

研究生学历、理学博士学位

职    称

教授

导师类别

博士生导师

专业领域

动物遗传育种与繁殖

研究方向

动物生殖生理调控

教育与工作经历

1997年9月-2001年7月，西北农业大学，兽医（公卫）攻读本科

2001年9月-2004年7月，西北农林科技大学，临床兽医专业攻读硕士

2004年9月-2007年7月，中国农业大学，生化与分子生物学专业攻读博士

2008年2月-2010年9月，美国华盛顿大学微生物系任研究助理

2011年8月-2013年7月，美国圣路易斯大学医学院博士后研究

2013年8月至今，在南京农业大学动物科技学院任教

联系方式

lgu@njau.edu.cn；025-84399690

奖励及荣誉

2019年获南京农业大学动物科技学院“丰泽农牧奖教金”；2019年校优秀硕士论文指导老师；指导的研究生获得国家奖学金4人次，校长奖学金1人次

参加学术团体及任职情况

承担科研项目

南京农业大学引进人才启动经费2013-2016；国家自然科学基金青年基金2015-2017；国家自然科学基金面上项目2018-2021，2020-2023

论文论著：

1. Liu Y, Li XY, He YF, Wang HJ, Gao Min, Han  LS, Qiu DH, Li L, Liu HL, Gu L. ASB7 Is a Novel Regulator of Cytoskeletal  Organization During Oocyte Maturation. Front  Cell Dev Biol. 2020 Nov 5; 8:595917.

2. He Y, Li X, Gao M, Liu H, Gu L. Loss of HDAC3  contributes to meiotic defects in aged oocytes. Aging Cell. 2019  Sep 9:e13036.

3. Li C, Huang Z, Gu L. SETD2 reduction adversely  affects the development of mouse early embryos. J Cell Biochem.  2019 Aug 12. doi: 10.1002/jcb.29325.

4. Gu L, Li X, Liu X, Gao M, He Y, Xiong B, Liu H.  HDAC3 inhibition disrupts the assembly of meiotic apparatus during  porcine oocyte maturation. J Cell Physiol. 2019  Jul; 234(7):10178-10183.

5. Li X, Gao M, He Y, Xiong B, Liu H, Gu L.  Intersectin-Cdc42 interaction is required for orderly meiosis in  porcine oocytes. J Cell Physiol. 2019 May; 234(5):7492-7497.

6. Gao M, Li X, He Y, Han L, Qiu D, Ling L, Liu H, Liu J, Gu  L. SIRT7 functions in redox homeostasis and cytoskeletal organization  during oocyte maturation. FASEB J. 2018 Jun.

7. Li X, Liu X, Gao M, Han L, Qiu D, Wang H, Xiong B, Sun SC,  Liu H, Gu L. HDAC3 promotes meiotic apparatus assembly in mouse  oocytes by modulating tubulin acetylation. Development. 2017  Oct 15; 144(20):3789-3797. 

8. Liu X, Zhang L, Wang P, Li X, Qiu D, Li L, Zhang J, Hou X,  Han L, Ge J, Li M, Gu L, Wang Q. Sirt3-dependent deacetylation of  SOD2 plays a protective role against oxidative stress in oocytes from  diabetic mice. Cell Cycle. 2017 Jul 3; 16(13):1302-1308.

9. Liu XH, Li XY, Ma RJ, Xiong B, Sun SC, Liu HL, Gu L. Tristetraprolin  functions in cytoskeletal organization during  mouse oocyte maturation. Oncotarget. 2016 Aug  16; 7(33):53330-53338.

10. Ma RJ, Zhang JQ, Liu XH, Li L, Liu HL, Rui R, Gu L,  Wang Q.  Involement of Rab6a in organelle rearrangement and cytoskeletal  organization during mouse oocyte maturation. Sci Rep. 2016  Mar 31; 6:23560.

11. Xu L, Ning H, Gu L, Wang QH, Lu WB, Peng H, Cui  W, Ying BL, Ross CR, Wilson GM, Wei L, Wold WS, Liu JG. Tristetraprolin  induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun  and NF-kB pathway. Oncotarget. 2015 Dec 8; 6(39):41679-31.

12. Gu L, Liu H, Gu X, Boots C, Moley KH, Wang Q. Metabolic  control of oocyte development: linking maternal nutrition and reproductive  outcomes. Cell Mol Life Sci. 2015 Jan; 72(2):251-71.

13. Gu L, Ning H, Qian X, Huang Q, Hou R, Almourani  R, Fu M, Blackshear PJ, Liu J. Suppression of IL-12 production by tristetraprolin  through blocking NF-kB nuclear translocation. J Immunol.  2013, 191(7):3922-30.  (Co-first author)

14. Qian X, Gu L, Ning H, Zhang Y, Hsueh EC, Fu  M, Hu X, Wei L, Hoft DF, Liu J. Increased Th17 cells in the tumor  microenvironment is mediated by IL-23 via tumor-secreted prostaglandin  E2. J Immunol. 2013, 190(11):5894-902. (Co-first author)　

15. Gu L, Wang Q, Sun QY. Histone modifications  during mammalian oocyte maturation: dynamics, regulation and  functions. Cell Cycle. 2010, 15; 9(10):1942-50.

16. Robertson DK, Gu L, Rowe RK, Beatty WL.  Inclusion biogenesis and reactivation of persistent Chlamydia trachomatis  requires host cell sphingolipid biosynthesis. PLoS pathogens.  2009, Nov; 5(11):e1000664.

17. Gu L, Wang Q, Wang CM, Hong Y, Sun SG, Yang SY,  Wang JG, Hou Y, Sun QY, Liu WQ. Distribution and expression of phosphorylated  histone H3 during porcine oocyte maturation. Mol Reprod  Dev. 2008, 75(1):143-9.