朱伟云

性    别

女

学历学位

研究生学历、哲学博士学位

职    称

教授

导师类别

博士生导师

专业领域

动物营养与饲料科学

研究方向

消化道微生物

教育与工作经历

1980年9月-1984年7月，北京农业大学（现中国农业大学），本科

1984年9月-1987年7月，北京农业大学（现中国农业大学），硕士

1987年7月-1989年8月，江苏省农业科学院，研究实习员

1989年9月-1992年10月，英国University of  Aberdeen，博士

1992年11月-1997年9月，英国草原与环境研究所，博士后研究员

1997年11月至今，南京农业大学，教授

联系方式

zhuweiyun@njau.edu.cn；025-84395523

奖励及荣誉

国家杰出青年基金获得者；

国务院“政府特殊津贴”获得者；

江苏省留学回国先进个人；

高等学校自然科学二等奖2项；

全国百篇优秀博士论文提名奖指导教授；

江苏省优秀博士论文奖（3篇）指导老师

参加学术团体及任职情况

中国畜牧兽医学会动物营养学分会副理事长，  全国饲料评审委员会委员、全国饲料工业协会标准化技术委员会委员；曾任国际反刍动物生理学国际咨询委员会委员，现为“动物营养”国家重点实验室学术委员会委员、江苏省消化道营养与动物健康重点实验室主任，动物消化道营养国家级国际联合研究中心主任。

承担科研项目

1.          国家自然科学基金重点项目：哺乳仔猪小肠微生物对母乳关键多糖代谢及其调节肠道黏膜糖基化和发育的机制研究，2021-2025,  主持

2.          国家重点研发计划课题：肠道微生物对肉品质的影响及其机制，  2018-2021，主持

3.          国家自然基金重点项目：生长猪肠道内微生物与营养代谢互作及其对机体整体代谢作用机制的研究 （31430082），2015-2019,主持。

4.          国家重点基础研究发展计划课题（973项目）：猪利用氮营养素的机制及营养调控（2013CB127300），首席科学家，2013-2017.

5.          国家自然科学基金项目：瘤胃纤维降解产甲烷过程中厌氧真菌与甲烷菌代谢关系机制及其作用，（31072052），2011-2013，主持。

论文论著：

近年主要代表论文：

1.           Wang  Huisong, Shen Junhua, Mu Chunlong, Gao Kan, Pi Yu, Zhu Weiyun. Low crude  protein diets supplemented with casein hydrolysate enhance the intestinal  barrier function and decrease the pro-inflammatory cytokine expression in the  small intestine of pigs. Animal Nutrition, 2021,  

2.           Shen  Junhua, Mu Chunlong, Wang Huisong, Huang Zan, Yu Kaifan, Zoetendal ErwinG,  Zhu Weiyun. Stimulation of gastric transit function driven by hydrolyzed  casein increases small intestinal carbohydrate availability and its microbial  metabolism. Molecular Nutrition & Food Research, 2020, 64, 2000250.

3.           Yu Pi , Chunlong Mu , Kan Gao, Zhuang Liu, Yu Peng,  and Weiyun Zhu.  Increasing the Hindgut Carbohydrate/Protein Ratio by Cecal Infusion of Corn  Starch or Casein Hydrolysate Drives Gut Microbiota-Related Bile Acid Metabolism  To Stimulate Colonic Barrier Function. mSystems.2020,5(3).

4.           Gao  K, Mu C, Aitak F,  Weiyun Zhu.Tryptophan  metabolism:a link between the gut microbiota and brain. Advances in  Nutrition, 2020, 3(3).

5.           Shen  Junhua, Wang Huisong, Pi Yu, Gao Kan, Zhu Weiyun, Casein hydrolysate  supplementation in low-crude protein diets increases feed intake and nitrogen  retention without affecting nitrogen utilization of growing pigs. Journal of  the Science of Food and Agriculture, 2020, 100(4): 1748-1756.

6.           Zhang  Chuanjian, Yu Miao, Yang Yuxiang, Mu Chunlong, Su Yong, Zhu Weiyun, Effect of  early antibiotic intervention on specific bacterial communities and immune  parameters in the small intestine of growing pigs fed different protein level  diets. Animal, 2020, 14 (10): 2042-2053.

7.           Mu  CL, Cai ZP, Bian GR, Du YM, Ma SQ, Su Y, Liu L, Voglmeir J, Huang RH,  Weiyun Zhu. New  insights into porcine milk N-glycome and the potential relation with  offspring gut microbiome. Journal of Proteome Research, 2019，18(3): 1114-1124.

8.           Gao,  K. , Pi, Y. , Mu, Chunlong, Farzi, A. , Liu, Z. , & Weiyun Zhu .  Increasing carbohydrate availability in the hindgut promotes hypothalamic  neurotransmitter synthesis: aromatic amino acids linking the microbiota‐brain  axis. Journal of Neurochemistry. 2019.

9.           Mu  CL,  Weiyun Zhu.  Antibiotic effects on gut microbiota, metabolism, and beyond. Applied  Microbiology and Biotechnology, 2019，103(23-24): 9277-9285.

10.        Mu  C, Bian GR, Su Y, Zhu WY. Differential effects of breed and nursing on  early-life colonic microbiota and immune status as revealed in a  cross-fostering piglet model. Applied and Environmental Microbiology, 2019,  85(9):e02510-18.

11.       Gao K,  Pi Y, Mu C L,  Weiyun Zhu.  Antibiotics-induced modulation of large intestinal microbiota altered  aromatic amino acid profile and expression of neurotransmitters in the  hypothalamus of piglets. Journal of Neurochemistry, 2018.

12.       Miao Yu , Chuanjian Zhang,  Yuxiang Yang,  Chunlong Mu , Yong Su,  Kaifan Yu , Weiyun Zhu . .Long-term  effects of early antibiotic intervention on blood parameters, apparent  nutrient digestibility, and fecal microbial fermentation profile in pigs with  different dietary protein levels. Journal of Animal Science &  Biotechnology, 2018.

13.        Yu  Miao, Zhang Chuanjian, Mu Chunlong, Zhu Weiyun. Increases in circulating  amino acids with in-feed antibiotics correlated with gene expression of  intestinal amino acid transporters in piglets. Amino Acids,  2017,  49:1587-1599.

14.       Mu CL,  Yang YX, Su Y, Zoetendal EG, Weiyun Zhu. Differences in  microbiota membership along the gastrointestinal tract of piglets and their  differential alterations following an early-life antibiotic intervention.  Frontiers in Microbiology. 2017, 8: 00797.

15.        Kaifan  Yu, Chunlong Mu, Yuxiang Yang, Yong Su, and Weiyun Zhu.Segment-specific  responses of intestinal epithelium transcriptome to in-feed antibiotics in  pigs. Physiol Genomics ,49: 582–591, 2017

1.         Peng  Yu, Yu Kaifan, Mu Chunlong, Hang Suqin, Che Lianqiang, Zhu Weiyun, 2017,  Progressive response of large intestinal bacterial community and fermentation  to the stepwise decrease of dietary crude protein level in growing pigs. Applied  Microbiology and Biotechnology, 2017, 101:5415-5426.

16.        Zhang  Chuanjian, Yu Miao, Yang Yuxiang, Mu Chunlong, Su Yong, Zhu Weiyun.  Differential effect of early antibiotic intervention on bacterial  fermentation patterns and mucosal gene expression in the colon of pigs under  diets with different protein levels. Applied Microbiology and Biotechnology, 2017  101(6):2493-2505.

17.       Gaorui  Bian, Shouqing Ma, Zhigang Zhu,Yong Su,Erwin G. Zoetendal, Roderick  Mackie,Junhua Liu,Chunlong Mu,1Ruihua Huang,Hauke Smidt,and Weiyun Zhu. Age, introduction of solid feed and  weaning are more important determinants of gut bacterial succession in piglets than breed  and nursing mother as revealed by a reciprocal cross-fostering model. Environmental Microbiology,2016,18(5):  1566-1577.

18.        Zhang  lingli, Mu Chunlong, He Xiangyu, Su Yong, Mao Shengyong, Zhang Jing, Smidt  Hauke, Zhu Weiyun, Effects of dietary fibre source on microbiota composition  in the large intestine of suckling piglets. FEMS Microbiology Letters, 2016, 363(14):1-6.   

19.        Mu  Chunlong, Yang Yuxiang, Luo Zhen, Guan Leluo, Zhu Weiyun. Colonic microbiome  and epithelial transcriptome are altered in rats fed a high-protein diet  compared with normal protein diet. The Journal of Nutrition, 2016, 146:474-483.

20.        Mu  Chunlong, Yang Yuxiang, Zhu Weiyun. Gut microbiota: the brain peacekeeper.  Frontiers in Microbiology, 2016, volume 7, article 345,  doi:10.3389/fmicb.2016.00345.

21.        Yuxiang  Yang, Chunlong Mu, Zhen Luo, Weiyun Zhu. Bromochloromethane, a methane  analogue, affects the microbiota and metabolic profiles of rat  gastrointestinal tract. Applied and Environmental Microbiology, 2016,  82:778-787.

22.        Ma  Shouqing, Ma Meilei, Mu Chunlong, Zhu Weiyun. Comparisons of blood  biochemical parameters, digestive enzyme activities and volatile fatty acid  profile between Meishan and Yorkshire piglets. 2016. Animal Nutrition, 1  (2015) 289-292.

23.        Su  Yong, Luo Yu-Heng, Zhang Ling-li, Smidt Hauke, Zhu Wei-Yun, 2015. Responses  in gut microbiota and fat metabolism to a halogenated methane analogue in  Sprague Dawley rats. Microbial Biotechnology, doi:10.1111/1751-7915.12256.

24.        Yu-Xiang  Yang, Zhao-Lai Dai, Wei-Yun Zhu, 2014. Important impacts of intestinal  bacteria on utilization of dietary amino acids in pigs. Amino Acids, Volume  46, Issue 11 (2014), Page 2489-2501.

25.       Yong  Su, Gaorui Bian, Zhigang Zhu, Hauke Smidt and Wei-yun Zhu. Early Methanogenic  Colonisation in the Faeces of Meishan and Yorkshire Piglets as Determined by  Pyrosequencing Analysis. Archaea: an International Micriobiological Journal. Volume  2013, Article ID 547908, 10 pages,