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教师目录-旧

申明

来源: 发布时间 : 2021-06-10 点击量:

   

申明




 


 

 

 


   

学历学位

研究生学历、农学博士学位

   

副教授

导师类别

硕士生导师

专业领域

动物遗传育种与繁殖

研究方向

哺乳动物生殖调控

教育与工作经历

2009年9月-2014年12月, 南京农业大学, 动物遗传育种与繁殖专业, 博士

2014年12月-2018年12月, 南京农业大学, 动物科技学院, 讲师

2019年1月-现在, 南京农业大学, 动物科技学院, 副研究员

联系方式

shenm2015@njau.edu.cn;逸夫楼2051

奖励及荣誉

1.高等学校科学研究优秀成果二等奖,卵泡闭锁与卵母细胞成熟的分子调控机制,教育部,20192.高等学校科学研究优秀成果二等奖,霉菌毒素对猪卵母细胞的毒性机制及防控措施,教育部,2023年;3.第一届江苏省畜牧兽医研究生论坛优秀墙报一等奖、二等奖各一项(通讯作者),江苏省畜牧兽医学会,2019.9.21;4.第十九次全国动物遗传育种学术讨论会优秀墙报奖(通讯作者),中国畜牧兽医学会,2017.10.16;5.第二十次全国动物遗传育种学术讨论会优秀墙报奖(通讯作者),中国畜牧兽医学会,2019.12.8;6.南京市第十一届自然科学优秀学术论文奖,南京市科协,2015.11.4; 7.动物科技学院2019年度“新希望六和”奖教金;8.指导本科生获得多项国家级、省级SRT项目;9.International Conference on Women’s health, Gynecology and Obstetrics 2018、Obstetrics and Gynecology Conference 2019、Chemistry Frontiers 2019、International Conference on Animal Science &  Veterinary Medicine (ICASVM -2020)、 BIT's 6th Annual World Congress of Animal Biotech (WCANB-2020)、World Congress of Women Health-2020 (WCWH-2020)、International Conference on Reproductive Health, Infertility and IVF 2020、中国畜牧兽医学会第四届“国家级四青人才”学术论坛、江苏省细胞与发育生物学学会生殖专业委员会会议、全国畜禽遗传标记学术研讨会等国内、外学术会议邀请作大会报告10.受Autophagy杂志主编、自噬领域权威专家Klionsky教授邀请参与自噬行业标准Guidelines for the Use  and Interpretation of Assays for Monitoring Autophagy (4th edition)的编写(2021年)11.研究成果入选Reproduction杂志2019年度高被引论文12.2022年度南京农业大学青年教师校长奖励金;13.南京农业大学钟山学术新秀

参加学术团体及任职情况

担任Journal of Pineal Research、Autophagy、Comprehensive  Reviews in Food Science and Food Safety、Clinical and  Translational Medicine、Frontiers in Cell and  Developmental Biology、Aging、GENE、BMC  Genetics、Animal Science Joural、Reproductive Science、International Journal  of Radiation Biology、Oxidative Medicine and Cellular  Longevity、Zygote、Frontiers in Endocrinology、Clinical Epigenetics、Cellular Signalling、La Prensa Medica、Journal of Integrative Agriculture、Frontiers in Bioscience-Landmark、畜牧与兽医等国内外期刊审稿人;受邀担任Frontiers in Cell and Developmental Biology杂志客座主编;英国生殖学会(SRF)会员;美国内分泌学会(Endocrine Society)会员;中国畜牧兽医学会动物繁殖学分会、动物遗传育种学分会、畜禽遗传标记学分会会员;江苏省动物学会理事;美国内分泌年会(ENDO 2021、2022、2023)论文评委;学术桥评审专家;江苏省科技咨询专家;广东省基础与应用基础研究基金项目评审专家;国家自然科学基金项目评审专家

承担科研项目

1.国家自然科学基金面上项目,31972564,低氧在启动猪有腔卵泡闭锁过程中对颗粒细胞周期/凋亡的影响及其机制研究,2020.1-2023.1257万,主持,在研;

2.国家自然科学基金青年基金,31601939FSH抑制氧化损伤猪卵巢颗粒细胞自噬的机制研究,2017.1-2019.1220万,主持,已结题;

3.江苏省自然科学基金面上项目,BK20221512FSH通过GAS6介导的低氧应答通路调控猪卵泡颗粒细胞增殖与凋亡的分子机制,2022.7-2025.610万,主持,在研;

4.江苏省自然科学基金青年基金,BK20150664,线粒体自噬在FSH抑制卵巢颗粒细胞氧化损伤中的作用机制研究,2015.7-2018.620万,主持,已结题;

5.中国博士后科学基金特别资助,2016T90476FSH通过自噬调控小鼠颗粒细胞氧化损伤的机制研究,2016.7-2018.715万,主持,已结题;

6.中国博士后基金面上项目,2015M581818Foxo1对氧化应激诱导猪颗粒细胞自噬和凋亡的调控研究,2015.12-2017.125万,主持,已结题;

7.江苏省博士后科研资助计划资助项目,1501047AFSH介导的保护性自噬对氧化应激引起的小鼠卵巢颗粒细胞凋亡的调控机制研究,2015.7-2017.76万,主持,已结题;

8.中央高校基本业务费,KJQN201705FSH抑制氧化损伤猪卵巢颗粒细胞的自噬机制研究,2017.1-2019.1210万,主持,已结题;

9.江苏省普通高校研究生科研创新基金(省立省助),CXZZ13_0306Foxo1在小鼠卵泡闭锁中的作用机制研究,2013.5-2014.53万,主持,已结题;

10.南京农业大学动物科技学院国家级四青人才项目,DKQB201903G0期颗粒细胞对低氧损伤抗性的机制研究,2019.4-2023.420万,主持,在研;

11.国家自然科学基金面上项目,31970413Ufm1泛素化样修饰系统E3连接酶--Ufl1缺失调控动物肝脏发育和原发性肝纤维化发生的分子机制,2020.1-2023.1259万,参与,在研

12.中央高校优秀青年团队项目,KYT2023002,大湖流域地方猪种高繁性状的遗传基础与分子调控机理研究,2023.1-2023.1260万,参与,在研

13.江苏省种业振兴揭榜挂帅项目,JBGS2021026,猪基因组编辑与选择关键技术创新,2022.1-2026.12500万,参与,在研

14.江苏省农业科技自主创新资金项目,CX(20)2011, 非洲猪瘟形势下提高母猪繁殖力的关键技术创新,2020.8-2023.7117万,参与,在研

15.江苏省大学生创新创业计划项目,202110307117Y,低氧通过诱发DNA氧化损伤抑制猪卵泡颗粒细胞增殖的研究,2021.6-2022.60.6万元,参与,结题

16.江苏省研究生科研创新计划项目, KYCX20_0602低氧抑制猪卵巢颗粒细胞周期的机制研究2020.4-2021.41.5万元参与结题

17.温氏科研基金项目YZ20181106BCXY027抗氧化剂原花青素提高母猪繁殖性能中试2019.12-2020.1229.7万元参与结题

18.国家重点研发项目,2021YFD1301200,北方区地方猪新品种(配套系)培育及良繁2021.12-2026.117210万元参与,在研 

论文论著:

本人主要从事哺乳动物卵泡发育的分子调控机理研究。研究侧重点包括:1. 引起卵泡氧化损伤的信号通路与效应分子;2. 卵泡液因子对卵泡氧化损伤的调控机制;3. 抗氧化剂对动物繁殖性能的改善;4.卵泡低氧环境对卵泡发育的影响及机制;5.卵泡发育过程中卵母细胞与颗粒细胞互作机制;6.卵泡微环境影响卵泡发育的表观遗传机理。在国家重点研发项目、国家自然科学基金、江苏省自然科学基金等项目支持下,已在AutophagyIF5=16.142)、Redox biologyIF5=11.271)、DevelopmentJournal of Biological ChemistryFaseb JournalEndocrinologyBiology of ReproductionCell Death & diseaseReproductionTheriogenology等领域前20%或影响因子>5 的刊物发表第一/通讯作者论文多篇。研究工作得到国内外同行的肯定,已被多本英文著作如Endocrine Cells: Advances in Research and  Application(第21-22 页,2013年出版,出版社Scholarly EditionsTM)、World Clinics: Dermatology-Acne(第72 页,2013  年出版,出版社Jaypee Brothers Medical Pub)、International Review of Cell and Molecular  Biology(第33 页,2018  年出版,出版社Academic Press)、IntechOpen Book Series Physiology, Volume 2: Endoplasmic  Reticulum(第80-81页,2019  年出版,出版社IntechOpen)收录并介绍。相关研究成果对于认清卵泡发育/闭锁转换规律、丰富和完善繁殖学理论、提高动物繁殖性能以及治疗人类排卵障碍相关疾病都具有重要意义。

 

一、10篇代表性论著

1Shen M, Jiang Y, Guan Z, Cao Y, Li L, Liu H, Sun SC. (2017) Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy. Autophagy. 13(8): 1364~1385, 第一兼通讯作者

2Shen M, Cao Y, Jiang Y, Wei Y, Liu H. (2018) Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent mechanism. Redox Biology. 18:138-157

3Li C, Liu Z, Wu G, Zang Z, Zhang JQ, Li X, Tao J, Shen M, Liu H. (2021) FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway. Development. 148(14):dev199453,通讯作者

4Li C, Meng X, Liu S, Li W, Zhang X, Zhou J, Yao W, Dong C, Liu Z, Zhou J, Li J, Tao J, Wu W, Shen M, Liu H. (2020) Oocytes and hypoxanthine orchestrate the G2-M switch mechanism in ovarian granulosa cells. Development. 147(13):dev184838,通讯作者

5Li C, Zhou J, Liu Z, Zhou J, Yao W, Tao J, Shen M, Liu H. (2020) FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway. FASEB J. 34(3):3631-3645,通讯作者

6Wu G, Li C, Tao J, Liu Z, Li X, Zang Z, Fu C, Wei J, Yang Y, Zhu Q, Zhang JQ, Shen M, Liu H. (2022) FSH mediates estradiol synthesis in hypoxic granulosa cells by activating glycolytic metabolism through the HIF-1α-AMPK-GLUT1 signaling pathway. J Biol Chem. 298(5):101830,通讯作者

7Shen, M., Lin, F., Zhang, J., Tang, Y., Chen, W. K., and Liu, H. (2012) Involvement of the upregulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress. J Biol Chem. 287(31):25727-40

8Li C, Liu Z, Li W, Zhang L, Zhou J, Sun M, Zhou J, Yao W, Zhang X, Wang H, Tao J, Shen M, Liu H. (2020) The FSH-HIF-1α-VEGF Pathway Is Critical for Ovulation and Oocyte Health but Not Necessary for Follicular Growth in Mice. Endocrinology. 161(4):bqaa038,通讯作者

9Li C, Liu Z, Zhou J, Meng X, Liu S, Li W, Zhang X, Zhou J, Yao W, Dong C, Cao Y, Li R, Chen B, Jiang A, Jiang Y, Ning C, Zhao F, Wei Y, Sun SC, Tao J, Wu W, Shen M, Liu H. (2020) Insulin-like growth factor-I prevents hypoxia-inducible factor-1 alpha-dependent G1/S arrest by activating cyclin E/cyclin-dependent kinase2 via the phoshatidylinositol-3 kinase/AKT/forkhead box O1/Cdkn1b pathway in porcine granulosa cells. Biol Reprod. 102(1):116-132,通讯作者

10Shen M, Liu Z, Li B, Teng Y, Zhang J, Tang Y, Sun SC, Liu H. (2014) Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells. Cell Death Dis. 5:e1475

 

其他论著

1Zhang X, Wei Y, Li X, Li C, Zhang L, Liu Z, Cao Y, Li W, Zhang X, Zhang J, Shen M, Liu H. (2022) The Corticosterone-Glucocorticoid Receptor-AP1/CREB Axis Inhibits the Luteinizing Hormone Receptor Expression in Mouse Granulosa Cells. Int J Mol Sci. 23(20):12454,通讯作者

2Zhang JQ, Lykke-Hartmann K, Shen M. (2021) Editorial: Involvement of Autophagy in Determining the Developmental Fate of Ovarian Follicles. Front Cell Dev Biol. 9:814135,通讯作者

3Liu Z, Li C, Wu G, Li W, Zhang X, Zhou J, Zhang L, Tao J, Shen M, Liu H. (2020) Involvement of JNK/FOXO1 pathway in apoptosis induced by severe hypoxia in porcine granulosa cells. Theriogenology. 154:120-127,通讯作者

4Cao Y, Shen M, Jiang Y, Sun SC, Liu HL. (2018) Melatonin reduces oxidative damage in mouse granulosa cells via restraining JNK-dependent autophagy. Reproduction. 155(3): 307~319, 共同一作兼通讯作者

5Wei Y, Li W, Meng X, Zhang L, Shen M, Liu H. (2019) Corticosterone Injection Impairs Follicular Development, Ovulation and Steroidogenesis Capacity in Mice Ovary. Animals (Basel). 9(12):1047,通讯作者

6)魏甲园; 邾倩; 杨亚星; 申明. (2022) 氯化钴通过诱发DNA氧化损伤抑制猪卵泡颗粒细胞增殖的研究, 畜牧兽医学报, 53(09):2982~2992,通讯作者

7Shen M, Jiang Y, Guan Z, Cao Y, Sun SC, Liu H. (2016) FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy. Sci Rep. 6: 38090~38090, 第一兼通讯作者

8Dai W, Liu K, Li R, Cao Y, Shen M, Tao J, Liu H. (2022) Trillin inhibits myoblast differentiation via increasing autophagy. Phytomedicine. 99:153962.

9Zhang J, Ren Q, Chen J, Lv L, Wang J, Shen M, Xing B, Wang X. (2022) Downregulation of miR-192 Alleviates Oxidative Stress-Induced Porcine Granulosa Cell Injury by Directly Targeting Acvr2a. Cells. 11.

10Tao J, Zhang L, Zhang X, Chen Y, Chen Q, Shen M, Liu H, Deng S. (2021) Effect of Exogenous Melatonin on the Development of Mice Ovarian Follicles and Follicular Angiogenesis. Int J Mol Sci. 22.

11Jiang Y, Shen M, Chen Y, Wei Y, Tao J, Liu H. (2021) Melatonin Represses Mitophagy to Protect Mouse Granulosa Cells from Oxidative Damage. Biomolecules. 11.

12Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, et al. (2021) DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function. Cell Death Dis. 12:416.

13Daniel J. Klionsky, Amal Kamal Abdel-Aziz, ..., Ming Shen, et al. (2021) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition). Autophagy, Feb 8;1-382,

14Tao JL, Zhang X, Zhou JQ, Li CY, Yang MH, Liu ZJ, Zhang LL, Deng SL, Zhang L, Shen M, et al. (2021) Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B-PKA-Caspase8/9 Pathway. Antioxidants (Basel, Switzerland). 10.

15Li R, Li B, Shen M, Cao Y, Zhang X, Li W, Tao J, Wu W, Liu H. (2020) LncRNA 2310043L19Rik inhibits differentiation and promotes proliferation of myoblast by sponging miR-125a-5p. Aging (Albany NY). 12:5625-5639.

16Liu S; Shen M; Li C; Wei Y; Meng X; Li R; Cao Y; Wu W; Liu H. (2019) PKCδ contributes to oxidative stress-induced apoptosis in porcine ovarian granulosa cells via activating JNK. Theriogenology, Jun;131:89-95, IF5=2.316

17Zhao F; Wu W; Wei Q; Shen M; Li B; Jiang Y; Liu K; Liu H. (2018) Exogenous adrenocorticotropic hormone affects genome-wide DNA methylation and transcriptome of corpus luteum in sows, Faseb Journal, fj201801081RRR, IF5=5.421

18Li B; Weng Q; Liu Z; Shen M; Zhang J; Wu W; Liu H. (2017) Selection of antioxidants against ovarian oxidative stress in mouse model, J Biochem Mol Toxicol, 31(12)

19Tang, Yiting; Pan, Bing; Zhou, Xin; Xiong, Kai; Gao, Qian; Huang, Lei; Xia, Ying; Shen, Ming; Yang, Shulin; Liu, Honglin; Tan, Tao; Ma, Jianjie; Xu, Xuehong; Mu, Yulian; Li, Kui. (2017) Wip1-dependent modulation of macrophage migration and phagocytosis, Redox Biology, 13:665-673,

20李烈川,申明,宁彩波,管志强,蒋毅,吴望军,刘红林. (2016) 过氧化氢诱导猪卵巢颗粒细胞自噬及其对凋亡的影响, 南京农业大学学报, 39(5):814~818

21Huang, Xian-Ju; Shen, Ming; Wang, Lizhong; Yu, Fengxiang; Wu, Wangjun; Liu, Hong-Lin. (2015) Effects of tributyltin chloride on developing mouse oocytes and preimplantation embryos, Microscopy and Microanalysis, 21(2):358~367

22Zhang JQ; Xing BS; Zhu CC; Shen M; Yu FX; Hong-Lin Liu. (2015) Protective effect of proanthocyanidin against oxidative ovarian damage induced by 3-nitropropionic acid in mice, Genet Mol Res, 14(1):2484~2494

23Yiting Tang; Kai Xiong; Ming Shen; Yulian Mu; Kui Li; Honglin Liu. (2015) CCAAT-enhancer binding protein (C/EBP) beta regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development, Mol Cell Biochem, 401(1-2):209~218

24Liu, Ze-Qun; Shen, Ming; Wu, Wang-Jun; Li, Bo-Jiang; Weng, Qian-Nan; Li, Mei; Liu, Hong-Lin. (2015) Expression of PUMA in Follicular Granulosa Cells Regulated by FoxO1 Activation During Oxidative Stress, Reproductive Sciences, 22(6):696~705

25Yiting Tang; Lan Liu; Ming Shen; Kai Xiong; Lei Huang; Qian Gao; Jingliang Wei; Tianwen Wu; Shulin Yang; Honglin Liu; Yulian Mu; Kui Li. (2015) Wip1 knockout inhibits the proliferation and enhances the migration of bone marrow mesenchymal stem cells, Experimental Cell Research, 334(2):310~322

26Lin F; Fu YH; Han J; Shen M; Du CW; Li R; Ma XS; Liu HL. (2014) Changes in the expression of Fox O1 and death ligand genes during follicular atresia in porcine ovary, Genet Mol Res, 13(3): 6638-6645

27Zhang, Jia-Qing; Shen, Ming; Zhu, Cheng-Cheng; Yu, Feng-Xiang; Liu, Ze-Qun; Ally, Nazim; Sun, Shao-Chen; Li, Kui; Liu, Hong-Lin. (2014) 3-Nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse, Plos One, 9(2): e86589~e86589

28)李诚瑜, 刘昭君, 申明, 李荣阳, 陶景丽, 吴望军, 刘红林. (2020) MSTN打靶猪的安全性分析, 农业技术与装备. 143-144+146

29)张良良, 张轩, 周佳奇, 申明, 陶景丽, 刘红林. (2022) 褪黑素与卵泡刺激素对小鼠卵巢卵泡发育及其血管生成的影响, 畜牧与兽医. 54:1-8

30)刘泽; 高峰; 周光宏; 申明. (2012) 牛蒡子苷对分化的小鼠C2C12细胞的影响, 营养学报, (04): 395~399

 

三、授权发明专利:

1. 刘红林,申明,吴望军 一种通过日粮添加原花青素提高母猪繁殖性能的方法,202248日,中国,ZL201811546492.9

2. 张家庆,李彦鹏,申明,施文创,王献伟,李冬冬,吕玲燕,苏格,卢清侠,孙浩,陈宝剑,李贺鹏,蒋凡,蒋立云 用于治疗猪卵巢囊肿的穿刺装置,2021212日,中国,ZL202021694469.7

3. 张家庆,李彦鹏,王献伟,孙茂,申明,左连亭,陈宝剑,徐明增,吕玲燕,张诚民,蒋凡,朱红卫,卢清侠,张红剑 一种成年猪外科手术用固定装置,2021212日,中国,ZL202021629992.1

4. 张家庆,李彦鹏,王献伟,胡言,蒋凡,孙茂,申明,施文创,陈宝剑,张毅,吕玲燕,李冬冬,卢清侠,蒋立云 一种提高母猪配种效率的模拟公猪,2021212日,中国,ZL202021621887.3

 

四、国家计算机软件著作权登记证书:

1. 张家庆,吕玲燕王献伟申明牛刚高彬文 猪子宫膜炎定性辅助诊断系统V1.020221206日,中国,2023SR0358390

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