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教师目录

钟翔

来源: 发布时间 : 2021-06-10 点击量:

   

钟翔

           

   

学历学位

研究生学历、农学博士学位

   

教授

导师类别

博士生导师

专业领域

动物营养与饲料科学

研究方向

动物营养与RNA表观遗传学;动物健康与营养免疫;植物提取物的开发与应用

教育与工作经历

20019-20056月,广西大学,动物科学专业攻读本科

20059-201012月,南京农业大学,动物营养与饲料科学专业攻读博士(硕博连读)

201012-至今,在南京农业大学动物科技学院任教

20086-20088月,美国密苏里哥伦比亚大学/普渡大学/NOVUS公司,实习工作

20144-20155月,美国芝加哥大学医学院,Eugene Chang教授实验室开展访问学者工作

201712-20199月,美国芝加哥大学化学系,Chuan He(何川)教授实验室开展访问学者工作

联系方式

zhongxiang@njau.edu.cn025-84396483

奖励及荣誉

钟山学者学术新秀; 2019“颐和青年创新奖;第三届中国畜牧兽医学会动物营养分会青年学者讲坛优秀奖(2019

参加学术团体及任职情况

美国动物科学学会(ASAS)会员;中国畜牧兽医学会动物营养学分会会员

承担科研项目

先后主持或参与了国家级与部省级课题及企业横向课题20多项。承担的主要科研课题有:

[1]      m6A mRNA甲基化修饰在免疫应激诱导仔猪肝脏损伤中的作用及营养调控,国家自然科学基金面上项目(主持),2019-2022

[2]      姜黄素(Curcumin)对断奶仔猪肠道黏膜免疫损伤调节的表观遗传组学机理研究,国家自然科学基金面上项目(主持),2015-2018  

[3]      MicroRNA介导IUGR仔猪免疫功能损伤的分子生物学机理研究,国家自然科学基金青年基金(主持),2013-2015

[4]      姜黄素基于m6A  RNA甲基化调控断奶仔猪树突状细胞免疫功能的机制研究,江苏省自然科学基金面上项目(主持),2016-2019

[5]      TGEV感染仔猪肠道的m6A RNA甲基化机制研究,江苏省人兽共患病学重点实验室开放课题(主持),2020-2022

[6]      母子一体化添加剂产品的开发及其作用机理研究,企业横向课题(主持),2020-2022

[7]      植物精油及酸化剂产品的开发及其抑制肠道有害菌作用的研究,企业横向课题(主持),2020-2022

[8]      生物钟对动物机体代谢及免疫调节的表观遗传学机制,学校聘请外国文教专家重点项目(主持),2016

[9]      IUGR仔猪早期免疫功能损伤的分子生物学机理研究,教育部博士点青年教师基金(主持),2012-2014

[10]   IUGR猪骨骼肌microRNA的筛选鉴定与功能研究,中央高校基本科研业务费自主创新重点项目(主持),2013-2016

[11]   植物甾醇调控断奶仔猪免疫功能的分子生物学机理研究,动物营养学国家重点实验室开放课题(主持),2012-2014

[12]   IUGR仔猪免疫功能损伤的分子生物学机理研究,南京农业大学青年科技创新基金(主持), 2011-2013

[13]   宫内发育迟缓猪的脂肪沉积机理及营养调控研究,国家自然科学基金面上项目(参与)

[14]   HSPsmTORIUGR猪胃肠道中的表达及其信号通路研究,国家自然科学基金面上项目(参与)

论文论著:

[1]      Yue  Feng, Haibo Dong, Bo Sun, Yun Hu, Yang Yang, Yimin Jia, Longfei Jia, Xiang  Zhong, and Ruqian Zhao. METTL3/METTL14 transactivation and m6A-dependent  TGF-β1 translation in activated Kupffer cells. Cellular and Molecular  Gastroenterology and Hepatology, 2021.

[2]       Jiamin  Wu, Yi Li, Jiayao Yu, Zhending Gan, Wenyao Wei, Chao Wang, Lili Zhang, Tian  Wang, Xiang Zhong#. Resveratrol attenuates High-Fat  Diet induced hepatic lipid homeostasis disorder and decreases m6A  RNA methylation. Front. Pharmacol, 2020,11:1800.

[3]       Jiamin  Wu, Zhending Gan , Ruhao Zhuo, Lili Zhang, Tian Wang and Xiang Zhong#.Resveratrol  attenuates aflatoxin B1-Induced ROS formation and increase of m6A  RNA methylation. Animals,2020,10:677.

[4]       Linda  Zhu, Xiaoxi Lu, Li Liu, Josef Voglmeir, Xiang Zhong#, Qinghua  Yu#. Akkermansia muciniphila protects intestinal mucosa  from damage caused by S. pullorum by initiating proliferation of intestinal  epithelium. Vet Res, 2020, 51:1-9.

[5]       Jiamin  Wu, Katya Frazier, Jingfei Zhang, Zhending Gan,Tian Wang, Xiang Zhong#.Emerging  role of m6A RNA methylation in nutritional physiology and metabolism.Obesity  Reviews (IF 10.17). 2019;1–10.

[6]      Gan Z, Wei W, Li Y, Wu J, Zhao Y, Zhang L, Wang T, Zhong  Xiang#. Curcumin and Resveratrol Regulate Intestinal Bacteria  and Alleviate Intestinal Inflammation in Weaned Piglets.Molecules. 2019, 24(7):1220.

[7]      Gan Z, Wei W, Wu J, Zhao Y, Zhang L, Wang T, Zhong Xiang#. Resveratrol and Curcumin  Improve Intestinal Mucosal Integrity and Decrease m6A RNA  Methylation in the Intestine of Weaning Piglets. ACS Omega. 2019,  4(17):17438-17446

[8]      Xiang  Zhong,  Jiayao Yu, Katya Frazier, Xiaocheng Weng, Yi Li, Candace M Cham, Kyle Dolan,  Xiaorong Zhu, Nathaniel Hubert, Yun Tao, Fanfei Lin, Kristina Martinez-Guryn,  Yong Huang, Tian Wang, Jianzhao Liu, Chuan He, Eugene B. Chang, and Vanessa  Leone   Circadian  Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA  Methylation. Cell reports (IF 8.65)2 5, 1816-1828. e1814  (2018).

[9]       Na  Lu, Xingmei Li, Jiayao Yu, Yi Li, Chao Wang, Lili Zhang, Tian Wang, Xiang  Zhong#, Curcumin Attenuates Lipopolysaccharide‐Induced Hepatic  Lipid Metabolism Disorder by Modification of m6A RNA Methylation in Piglets. Lipids  53, 53-63 (2018).

[10]   Jiayao  Yu, Yi Li, Tian Wang, Xiang Zhong#, Modification of  N6-methyladenosine RNA methylation on heat shock protein expression. PLoS  One 13, e0198604 (2018).

[11]    Niu  Y, He J, Zhao Y, Shen M, Zhang L, Xiang Zhong, Wang C, Wang T. Effect  of Curcumin on Growth Performance, Inflammation, Insulin level, and Lipid  Metabolism in Weaned Piglets with IUGR. Animals (Basel). 2019, 9:9(12). E1098

[12]    Niu  Y, He J, Ahmad H, Shen M, Zhao Y, Gan Z, Zhang L, Zhong X, Wang C, Wang T.  Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates  Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth  Retardation. Nutrients. 2019, 5;11(12). pii: E2978.

[13]    Niu  Y, He J, Ahmad H, Wang C, Zhong X, Zhang L, Cui T, Zhang J, Wang T. Curcumin  attenuates insulin resistance and hepatic lipid accumulation in a rat model  of intra-uterine growth restriction through insulin signalling pathway and  sterol regulatory element binding proteins. Br J Nutr. 2019 Jun 25:1-9.

[14]    Jintian  He, Yu Niu, Fei Wang, Chao Wang, Tao Cui, Kaiwen Bai, Jingfei Zhang, Xiang  Zhong, Lili Zhang, Tian Wang, Dietary curcumin supplementation attenuates  inflammation, hepatic injury and oxidative damage in a rat model of  intra-uterine growth retardation. Br. J. Nutr. 120, 537-548 (2018).

[15]    Chao  Wang, Ligen Zhang, Zhixiong Ying, Jintian He, Le Zhou, Lili Zhang, Xiang  Zhong, Tian Wang, Effects of Dietary Zinc Oxide Nanoparticles on Growth,  Diarrhea, Mineral Deposition, Intestinal Morphology, and Barrier of Weaned  Piglets. Biol. Trace Elem. Res., 1-11 (2018).

[16]    Chao  Wang, Ruiming Zhang, Le Zhou, Jintian He, Qiang Huang, Farman A Siyal, Lili  Zhang, Xiang Zhong, Tian Wang, Intrauterine growth retardation  promotes fetal intestinal autophagy in rats via the mechanistic target of  rapamycin pathway. Journal of Reproduction and Development 63, 547-554  (2017).

[17]    Chao  Wang, Ligen Zhang, Weipeng Su, Zhixiong Ying, Jintian He, Lili Zhang, Xiang  Zhong, Tian Wang, Zinc oxide nanoparticles as a substitute for zinc oxide  or colistin sulfate: Effects on growth, serum enzymes, zinc deposition,  intestinal morphology and epithelial barrier in weaned piglets. PLoS One  12, e0181136 (2017).

[18]    Chao  Wang, Kang Cheng, Le Zhou, Jintian He, Xiaochuan Zheng, Lili Zhang, Xiang  Zhong, Tian Wang, Evaluation of long-term toxicity of oral zinc oxide  nanoparticles and zinc sulfate in mice. Biol. Trace Elem. Res. 178,  276-282 (2017).

[19]    Chao  Wang, Jianjun Lu, Le Zhou, Jun Li, Jiaman Xu, Weijian Li, Lili Zhang, Xiang  Zhong, Tian Wang, Effects of long-term exposure to zinc oxide  nanoparticles on development, zinc metabolism and biodistribution of minerals  (Zn, Fe, Cu, Mn) in mice. PLoS One 11, e0164434 (2016).

[20]    Li  Dong, Xiang Zhong, Jintian He, Lili Zhang, Kaiwen Bai, Wen Xu, Tian  Wang, Xuexin Huang, Supplementation of tributyrin improves the growth and  intestinal digestive and barrier functions in intrauterine growth-restricted  piglets. Clin. Nutr. 35, 399-407 (2016).

[21]    Li  Dong, Xiang Zhong, Lili Zhang, Lingrui Kong, Yili Kong, Tao Kou, Tian  Wang, Impaired intestinal mucosal immunity is associated with the imbalance  of T lymphocyte sub-populations in intrauterine growth-restricted neonatal  piglets. Immunobiology 220, 775-781 (2015).

[22]    Li  Dong, Xiang Zhong, Hussain Ahmad, Wei Li, Yuanxiao Wang, Lili Zhang,  Tian Wang, Intrauterine growth restriction impairs small intestinal mucosal  immunity in neonatal piglets. J. Histochem. Cytochem. 62, 510-518  (2014).

[23]   Xiang  Zhong,  S Gao, JJ Wang, L Dong, J Huang, LL Zhang, T Wang, Effects of linseed oil and  palm oil on growth performance, tibia fatty acid and biomarkers of bone  metabolism in broilers. Br. Poult. Sci. 55, 335-342 (2014).

[24]    Xiang  Zhong,  Wei Li, Xuexin Huang, Yuanxiao Wang, Lili Zhang, Yanmin Zhou, Ahmad Hussain,  Tian Wang, Effects of glutamine supplementation on the immune status in  weaning piglets with intrauterine growth retardation. Archives of animal  nutrition 66, 347-356 (2012).

[25]    Xiang  Zhong,  Wei Li, Xuexin Huang, Lili Zhang, Mireguli Yimamu, Nasir Raiput, Yanmin Zhou,  Tian Wang, Impairment of cellular immunity is associated with overexpression  of heat shock protein 70 in neonatal pigs with intrauterine growth  retardation. Cell Stress Chaperones 17, 495-505 (2012).

[26]    Xuhui  Zhang, Xiang Zhong, Yanmin Zhou, Gaiqin Wang, Haiming Du, Tian Wang,  Dietary RRR-α-tocopherol succinate attenuates lipopolysaccharide-induced  inflammatory cytokines secretion in broiler chicks. Br. J. Nutr. 104,  1796-1805 (2010).

[27]    Xiang  Zhong,  Tian Wang, Xuhui Zhang, Wei Li, Heat shock protein 70 is upregulated in the  intestine of intrauterine growth retardation piglets. Cell Stress  Chaperones 15, 335-342 (2010).

[28]   魏思宇,甘振丁,韦文耀,吴嘉敏,夏振海,陈璟玥,王恬,钟翔#. 姜黄素和白藜芦醇联用对断奶仔猪消化酶活性和胰腺抗氧化功能的影响[J].南京农业大学学报,2020,43(04).

[29]   李毅,夏振海,魏思宇,陈璟玥,陈安格,李自强,陈佳翎,余嘉瑶,王恬,钟翔#.白藜芦醇对高脂诱导肥胖小鼠生长性能及肝脏糖脂代谢、能量代谢的影响[J].食品工业科技,2018,39(19):302-308.

[30]   余嘉瑶,李毅,王恬, 钟翔#.日粮中添加姜黄素对免疫应激断奶仔猪肠道抗氧化能力及糖代谢的影响[J].畜牧与兽医,2018,50(05):51-55.

[31]   芦娜,邱静芸,应志雄,郑永明,王恬, 钟翔#.日粮添加不同水平姜黄素对断奶仔猪生产性能、消化率和血液指标的影响[J].家畜生态学报,2017,38(01):30-35.

[32]   宋志华,程康,张婧菲,王超,钟翔,张莉莉,王恬.酶解青蒿对热应激肉鸡消化功能的影响[J].南京农业大学学报,2018,41(01):126-131.

[33]   张莉莉,王远孝,孔一力,周根来,王超,钟翔,王恬.精氨酸对子宫内发育迟缓仔猪抗氧化功能和精氨酸代谢的影响[J].南京农业大学学报,2017,40(06):1111-1118.

[34]   钟翔. 生物钟与营养生理代谢研究进展[A]. 中国畜牧兽医学会动物营养学分会.中国畜牧兽医学会动物营养学分会第十届全国代表大会暨十二届学术研讨会论文集[C].中国畜牧兽医学会动物营养学分会:中国畜牧兽医学会,2016:8.

[35]   芦娜, 钟翔#. 姜黄素对断奶仔猪生产性能和血脂代谢的影响[A]. 中国畜牧兽医学会动物营养学分会.中国畜牧兽医学会动物营养学分会第十二次动物营养学术研讨会论文集[C].中国畜牧兽医学会动物营养学分会:中国畜牧兽医学会,2016:1.

[36]   胡志萍,寇涛,张莉莉,钟翔,王恬.不同剂型维生素E对肉鸡生长性能、血清生化和抗氧化功能的影响[J].中国粮油学报,2016,31(04):118-123.

[37]   芦娜,王恬, 钟翔#.不同的丁酸产品在猪禽生产中的应用研究进展[J].动物营养学报,2015,27(02):359-368.

[38]   寇涛,胡志萍,张莉莉,钟翔,王恬.二甲基甘氨酸钠对肉鸡生产性能、养分表观利用率及内源消化酶活性的影响[J].南京农业大学学报,2015,38(01):140-145.

[39]   孙得发,董丽,屈长波,吕佳琪,钟翔,王恬.α-生育酚琥珀酸酯对肉鸡脂质过氧化及脂代谢的影响[J].南京农业大学学报,2015,38(01):134-139.

[40]   钟翔,王恬.Hsp70对胃肠道黏膜的保护及其免疫调控作用[J].畜牧兽医学报,2014,45(04):517-523.

[41]   寇涛,董丽,安文俊,张莉莉,钟翔,王恬.日粮中不同油脂对肉鸡小肠组织形态的影响[J].中国粮油学报,2014,29(01):72-76+82.

[42]   钟翔,李刚,徐生林,陈俊杰,王恬.鸡舍环境因子对蛋鸡健康和生长的影响[J].畜牧与兽医,2013,45(03):101-103.

[43]   董丽,安文俊,李伟,张莉莉,钟翔,王恬.不同配比油脂对肉仔鸡小肠形态的影响[J].畜牧与兽医,2013,45(01):1-5.

[44]   郑荷花,杨丽,李伟,张莉莉,钟翔,王恬.丁酸钾对断奶仔猪生长性能、腹泻率和养分消化率的影响[J].饲料研究,2013(01):1-4.

[45]   王明发,田亚东,钟翔,康相涛,冯培刚,王恬.饲粮中不同锌源及锌水平对固始鸡和AA肉鸡肝脏金属硫蛋白含量及基因表达的影响[J].南京农业大学学报,2012,35(06):111-117.

[46]   钟翔,李刚,张桂英,陈俊杰,王恬.无线传感器网络技术及其在畜禽舍环境监控中的应用[J].中国家禽,2012,34(22):41-43.

[47]   钟翔,李兴美,李伟,黄雪新,张莉莉,王恬.肠上皮细胞RNA干扰Hsp70基因转染条件的研究[J].生物技术通报,2011(09):181-186.

[48]   邱梅平,钟翔,王恬.植酸酶与钙的互作效应在畜禽生产中的应用研究进展[J].畜牧与兽医,2010,42(05):92-95.

[49]   李伟,钟翔,王恬.IUGR新生仔猪胃肠道发育早期营养调控的研究进展[J].畜牧与兽医,2010,42(04):92-95.

[50]   李伟,钟翔,华荣蓉,王恬.植物甾醇对断奶仔猪生产性能和血液生化指标的影响[J].家畜生态学报,2010,31(02):58-63.

[51]   钟翔,黄小国,陈莎莎,李伟,王恬.丁酸钠对断奶仔猪生长性能和肠道消化酶活性的影响[J].动物营养学报,2009,21(05):719-726.

[52]   钟翔,陈莎莎,李伟,黄小国,王恬.丁酸钠对断奶仔猪生产性能和肠道形态的影响[J].饲料研究,2009(10):19-22.

[53]   包红朵,钟翔,王恬.甜菜碱与脂肪代谢[J].家畜生态学报,2008(03):6-10.

[54]   王恬,钟翔.仔猪肠黏膜营养与肠道修复[J].饲料工业,2008(02):2-7.

[55]   王远孝,李雁,钟翔,黄进,王恬.猪用发酵床的研究与应用[J].家畜生态学报,2007(06):139-142.

[56]   钟翔,张莉莉,梁国旗,杜伟,赵念,王远孝,王恬.豆油和油脂粉对断奶仔猪生产性能的影响[J].饲料研究,2007(05):4-7.

 

 

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