邓明田

性    别

男

学历学位

研究生学历、农学博士学位

职    称

副研究员

导师类别

硕士生导师

专业领域

动物遗传育种与繁殖

研究方向

动物胚胎发育

教育与工作经历

2009/09-2013/06 安徽农业大学 动物科学 学士

2013/09-2018/09 南京农业大学 动物遗传育种与繁殖 农学博士

2018/12-2022/12 南京农业大学 动物科技学院 助理研究员

2023/01-至今    南京农业大学 动物科技学院 副研究员

联系方式

mtdeng@njau.edu.cn；025-84395381

奖励及荣誉

第十九届中国畜牧兽医学会动物繁殖学分会优秀论文

参加学术团体及任职情况

Discover Life杂志编委，Biology of Reproduction, Theriogenology, Frontiers in cell and developmental biology审稿人；Frontiers in Endocrinology客座编辑

承担科研项目

1. 国家自然科学基金委员会,青年科学基金项目,32102546,LncRNA-loc102177005通过RNA结合蛋白YTHDF2调控山羊合子基因组激活的机制研究,2022-01-01至2024-12-31,30万元,在研,主持

2. 江苏省基础研究计划（自然科学基金）-青年基金，LncRNA lnc-2217对山羊合子基因组激活的表观遗传调控机制研究，2020/07-2023/06，20万，在研，主持

3. 中国博士后科学基金，Lnc-3712靶向Kdm5b调控山羊核移植胚胎重编程的研究，2019/07-2021/06，8万，在研，主持

4. 国家自然科学基金委员会,国际(地区)合作与交流项目,32261143734,中埃绵羊子宫内膜容受性分子调控机理解析,2023-01-01至2025-12-31,200万元,在研,参与

5. 国家自然科学基金委员会,面上项目,32172735,低氧通过m6A甲基化修饰参与调控山羊早期胚胎发育的机制研究,2022-01-01至2025-12-31,58万元,在研,参与

6. 国家自然科学基金委员会,面上项目,32072737,LncRNA通过激活TGFβ/SMAD2信号通路调控湖羊垂体促性腺激素分泌的机制研究,2021-01-01至2024-12-31,58万元,在研,参与

7. 国家自然科学基金委员会,面上项目,31972569,m6A甲基化修饰参与调控山羊体细胞核移植胚胎母源-合子转换期重编程的研究,2020-01-01至2023-12-31,59万元,资助期满,参与

8. 科技部-国家重点研发计划子课题，小体型特色肉用山羊新品系培育，2022年12月至2027年11月,在研,参与

论文论著：

1) Chen, X, Yang, Y, Cai, Y, Yang H, Wang F, Deng, M (2023), Lysine-Specific Demethylase 4D Is Critical for the Regulation of the Cell Cycle and Antioxidant Capacity in Goat Fibroblast Cells, Biology, 12(8):1095

2) Cai Y, Liu Z, Zhang G, Yang Y, Zhang Y, Wang F, Deng M (2023) miR-101-5p overexpression suppresses the proliferation of goat spermatogonial stem cells by targeting EZH2, Animal Reproduction Science 255(2):107281

3) Deng, M, Chen B, Liu Z, Wan, Y, Li, D, Yang, Y, Wang, F (2022). YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development. Cell and Bioscience, 12(1): 12

4) Deng, M, Wan, Y, Chen, B, Dai X, Liu, Z, Yang, Y, Cai, Y, Zhang, Y, Wang, F (2021). Long non-coding RNA lnc_3712 impedes nuclear reprogramming via repressing Kdm5b. Molecular Therapy-Nucleic Acids, 24: 54-66

5) Deng, M, Chen, B, Yang Y, Wan Y, Liu, Z, Fu, J, Wang, F (2021). Characterization of transcriptional activity during ZGA in mammalian SCNT embryo. Biology of Reproduction, 105(4): 905-917

6) Deng, M, Chen, B, Liu, Z, Cai, Y, Wan, Y, Zhang, G, Fan, Y, Zhang, Y, and Wang, F (2020). YTHDF2 Regulates Maternal Transcriptome Degradation and Embryo Development in Goat. Frontiers in cell and developmental biology 8: 580367

7) Deng, M, Liu, Z, Ren, C, Zhang, G, Pang, J, Zhang, Y, Wang, F, and Wan, Y (2018). Long noncoding RNAs exchange during zygotic genome activation in goat. Biology of reproduction 99: 707-717

8) Deng, M, Liu, Z, Chen, B, Wan, Y, Yang, H, Zhang, Y, Cai, Y, Zhou, J, and Wang, F (2020). Aberrant DNA and histone methylation during zygotic genome activation in goat cloned embryos. Theriogenology 148: 27-36

9) Deng, M, Liu, Z, Ren, C, An, S, Wan, Y, and Wang, F (2019). Highly methylated Xist in SCNT embryos was retained in deceased cloned female goats. Reproduction, Fertility and Development 31: 855-866

10) Deng, M, Liu, Z, Chen, B, Cai, Y, Wan, Y, and Wang, F (2020). Locus-Specific Regulation of Xist Expression Using the CRISPR-Cas9-Based System. DNA and cell biology 39: 572-578

11) Deng, M, Zhang, G, Cai, Y, Liu, Z, Zhang, Y, Meng, F, Wang, F, and Wan, Y (2020). DNA methylation dynamics during zygotic genome activation in goat. Theriogenology 156: 144-154

12) Deng, M, Chen, B, Liu, Z, Cai, Y, Wan, Y, Zhou, J, and Wang, F (2020). Exchanges of histone methylation and variants during mouse zygotic genome activation. Zygote (Cambridge, England) 28: 51-58

13) Deng, M, Ren, C, Liu, Z, Zhang, G, Wang, F, and Wan, Y (2017). Epigenetic status of H19-Igf2 imprinted genes and loss of 5-hydroxymethylcytosine in the brain of cloned goats. Cellular reprogramming 19: 199-207

14) Cai, Y#, Deng, M#, Zhang, Q, Liu, Z, Wang, L, Sheng, WW, Zhang YL, You, PH, Z, Wang, ZY, and Wang, F. Effects of dietary betaine supplementation on biochemical parameters of blood and testicular oxidative stress in Hu sheep. Theriogenology, 2021, 164: 65-73 (co-first author)

15) Wan, Y#, Deng, M#, Zhang, G, Ren, C, Zhang, H, Zhang, Y, Wang, L, and Wang, F (2016). Abnormal expression of DNA methyltransferases and genomic imprinting in cloned goat fibroblasts. Cell biology international 40: 74-82 (co-first author)