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教师目录

张定东

来源: 发布时间 : 2021-06-10 点击量:

   

张定东

   

学历学位

博士

   

教授

导师类别

博士生导师

专业领域

水产养殖/水产动物营养与饲料

研究方向

水产动物营养生理学;营养表观遗传学

教育与工作经历

1、教育经历  (education background)

(1) 2003.09-2007.10,东南大学,生物科学与医学工程学院,生物医学工程专业, 博士

(2) 1998.09-2001.07,南京农业大学,渔业学院,水产养殖专业, 硕士

(3) 1994.09-1998.07,南京农业大学,渔业学院,淡水渔业专业, 本科

2、工作经历  (employment record)

(1) 2013.02-至今,南京农业大学,动物科技学院,副教授、教授

(2) 2017.12-2018.12,  Vanderbilt University, School of Medicine, the U.S.A. (Visiting  Scholar)

(3) 2010.09-2011.03,  University of Munich, Department of Medicine II, Germany. (Visiting  Scholar)

(4) 2001.08-2013.02,金陵科技学院,动物科学与技术学院,讲师、副教授

联系方式

邮箱zdd_7597@njau.edu.cn  办公室:逸夫楼3045

手机13851494442

奖励及荣誉

1)江苏省“333高层次人才培养工程”第三层次培养对象(2011-2015);

2)江苏省高校“青蓝工程”优秀青年骨干教师培养对象(2008);

32013年度江苏省海洋与渔业科技创新奖三等奖(5/11);

42016年度江苏省科技进步奖二等奖(5/11);

52016年度江苏省海洋与渔业科技创新奖一等奖(3/11);

62016年度动科院“北正农”奖教金;

72018年度中国水产科学研究院科技进步奖一等奖(11/20);

82019年度江苏省高层次创新创业人才引进计划科技副总” 

参加学术团体及任职情况

1)江苏省海洋湖沼学会理事;

2  江苏省水产学会会员;

3)中国营养学会会员;

4)美国糖尿病学会(ADA)会员。

承担科研项目

1)江苏省农业科技自主创新项目,CX(20)3109,中华绒螯蟹一龄蟹种性早熟机制及防早熟饲料研究,2020.08-2022.0730万,主持。  2)南京农业大学泰州研究院项目,水产养殖尾水生态治理科技示范子课题,2020/01-2020/1210万,主持。

3)国家自然科学基金(面上项目),31972801,高糖负荷下团头鲂CaSRGCGR沉默诱导的α-细胞增生中的作用,2020/01-2023/1258万,主持。

4)国家科技支撑项目(2013BAD20B05)课题子任务,L0201300242,长三角现代农业区优质水产养殖技术集成与示范,2013/01-2015/1251万,主持。

5)江苏省农业科技自主创新项目,CX(16)1004-09,池塘工业化养殖下鱼类营养品质调控技术研发与应用,2016/06-2019/0640万,主持。

6)江苏省农业科技自主创新项目,CX(15)1011-04,河蟹新品种营养需求与饲料研究关键技术集成,2015/06-2017/1250万,主持。

7)江苏省水产三新工程项目,Y2014-33,蟹池多品种混养模式下的饲料配套技术研究与集成示范,2014/03-2016/1245万,主持。

8)农业部淡水渔业与种质资源利用重点实验室开放基金项目,KF201310miRNA及其靶基因在团头鲂免疫调控中的作用与机制研究,2013/07-2015/066万,主持。

9)国家自然科学基金(青年基金),60901053,尿沉淀细胞DNA甲基化高通量检测方法的研究,2010/01-2012/1220万,主持。

10)企业横向项目(苏宁现代农业股份有限公司),5万,主持。

11)企业横向项目(江苏海普瑞饲料有限公司),80万,主持。

论文论著:

一、发表论文Publication,*corresponding  author; # co-first author

2013 – Present (focus on aquatic animal  nutrition)                                                               

1. Fan  Gao#, Mingyang Liu#, Jianqing Tang, Aimin Wang, Hongyan  Tian, Chuang Wen, Cheng Chi, Guangzhen Jiang, Xiangfei Li, Wenbin Liu, Dingdong  Zhang*. Partial replacement of dietary fish oil by beef tallow does not  impair antioxidant capacity and innate immunity of red swamp crayfish, Procambarus  clarkia. Aquaculture Research. 2021, 00:1–12.

2.  Chang He, Xiaoyan Jia, Li Zhang, Fan Gao, Weibo Jiang, Chuang Wen, Cheng Chi,  Xiangfei Li, Guangzhen Jiang, Haifeng Mi, Wenbin Liu, Dingdong Zhang*.  Dietary berberine can ameliorate glucose metabolism disorder of Megalobrama  amblycephala exposed to a high-carbohydrate diet. Fish  Physiology and Biochemistry, 2021, 47: 499-513.

3.  Fan Gao, Jie Liu, Aimin Wang, Bo Liu, Hongyan Tian, Xiaochuan Zheng, Xiaoyan  Jia, Chang He, Xiangfei Li, Guangzhen Jiang, Cheng Chi, Wenbin  Liu, Dingdong Zhang*. Dietary lipid sources modulate the intestinal  transport of fatty acids in the red swamp crayfish Procambarus  clarkii. Aquaculture, 2020, 521:735091.

4.  Jie Liu, Erteng Jia, Huajuan Shi, Xiangfei Li, Guangzhen Jiang, Cheng Chi,  Wenbin Liu, Dingdong Zhang*. Selection of reference genes for miRNA  quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy  metabolism in Megalobrama amblycephala. Fish Physiology and  Biochemistry, 2019, 45:1663-1681.

5.  Hongyan Tian, Dingdong Zhang*, Xiangfei Li, Guangzhen Jiang, Wenbin Liu.  Photoperiod affects blunt snout bream (Megalobrama amblycephala)  growth, diel rhythm of cortisol, activities of antioxidant enzymes and mRNA  expression of GH/IGF-I. Comparative Biochemistry and Physiology, Part B,  2019, 233: 4-10.

6.  Jean‐Jacques Yao Adjoumani, Kenneth Prudence Abasubong, Francis Phiri, Chao  Xu, Wenbin Liu, Dingdong Zhang*. Effect of dietary betaine and choline  association on lipid metabolism in blunt snout bream fed a high‐fat  diet. Aquaculture Nutrition, 2019, 25:1017-1027.

7.  Erteng Jia, Xiaochuan Zheng, Huihui Cheng, Jie Liu, Xiangfei Li, Guangzhen  Jiang, Wenbin Liu, Dingdong Zhang*. Dietary fructooligosaccharide can  mitigate the negative effects of immunity on Chinese mitten crab fed a high  level of plant protein diet. Fish and Shellfish Immunology, 2019, 84:100-107.

8.  Erteng Jia#, Yanan Yan#, Man Zhou, Xiangfei Li,  Guangzhen Jiang, Wenbin Liu, Dingdong Zhang*. Combined effects of  dietary quercetin and resveratrol on growth performance, antioxidant  capability and innate immunity of blunt snout bream (Megalobrama  amblycephala). Animal Feed Science and Technology, 2019, 256:114268.

9.  Si-lei Xia, Xiang-fei Li, Kenneth Prudence Abasubong, Chao Xu, Hua-juan Shi,  Wen-bin Liu*, Ding-dong Zhang*. Effects of dietary glucose and starch  levels on the growth, apparent digestibility, and skin-associated mucosal  non-specific immune parameters in juvenile blunt snout bream (Megalobrama  amblycephala). Fish and Shellfish Immunology, 2018, 79:193-201.

10. Dingdong  Zhang*, Yanan Yan, Hongyan Tian, Guangzhen Jiang, Xiangfei Li, Wenbin  Liu. Resveratrol supplementation improves lipid and glucose metabolism in  high-fat diet-fed blunt snout bream. Fish Physiology and Biochemistry,  2018, 44:163-173.

11.  贾二腾,闫明军,赖起铖,罗文涛,蒋广震,刘文斌,张定东*. 中华绒螯蟹的摄食节律中国水产科学,2018,25(3):546-554.

12.  Jean-Jacques Yao Adjoumani, Kaizhou Wang, Man Zhou, Wenbin Liu, Dingdong  Zhang*. Effect of dietary betaine on growth performance, antioxidant capacity  and lipid metabolism in blunt snout bream fed a high-fat diet. Fish  Physiology and Biochemistry, 2017, 43:1733-1745

13.  Erteng Jia, Zhuoqin Li, Yunfei Xue, Guangzhen Jiang, Xiangfei Li, Wenbin  Liu, Dingdong Zhang*. Effects of dietary fructooligosaccharide on the  growth, antioxidants, immunity and disease resistance of Chinese mitten  crab. Aquaculture, 2017, 481:154–161.

14.  闫亚楠,夏斯蕾,田红艳,徐超,贾二腾,刘文斌,张定东*. 白藜芦醇对高脂胁迫团头鲂抗氧化能力、非特异免疫机能和抗病力的影响水生生物学报,2017,41(1):155-164.

15. 张定东,李俊怡,王冰柯,李向飞,蒋广震,李鹏飞,蔡万存,刘文斌*. 胆碱对高脂胁迫的团头鲂肝脏抗氧化、组织结构和免疫力的影响水产学报,2017,41(3):438-447.

16.  Kang-Le Lu#, Ding-Dong Zhang#, Li-Na Wang, Wei-Na  Xu, Wen-Bin Liu*. Molecular characterization of carnitine  palmitoyltransferase IA in Megalobrama amblycephala and  effects on its expression of feeding status and dietary lipid and  berberine. Comparative Biochemistry and Physiology, Part B, 2016,  191:20-25.

17. Dingdong  Zhang, Kangle Lu, Guangzhen Jiang, Wenbin Liu*, Zaijie Dong*, Hongyan Tian,  Xiangfei Li. A global transcriptional analysis of Megalobrama  amblycephala revealing the molecular determinants of diet-induced  hepatic steatosis, Gene, 2015, 570(2):255-263.

18.  Hong-Yan Tian, Ding-Dong Zhang*, Chao Xu, Fei Wang, Wen-Bin Liu*.  Effects of light intensity on growth, immune responses, antioxidant  capability and disease resistance of juvenile blunt snout bream Megalobrama  amblycephala. Fish and Shellfish Immunology, 2015, 47(2):674-680.

19.  Hongyan Tian, Dingdong Zhang*, Xiangfei Li, Chunnuan Zhang, Yu Qian,  Wenbin Liu*. Optimum feeding frequency of juvenile blunt snout bream Megalobrama  amblycephala. Aquaculture, 2015, 437:60-66.

20. Dingdong  Zhang, Kangle Lu, Zaijie Dong*, Guangzhen Jiang, Weina Xu, Wenbin Liu*. The  effect of exposure to a high-fat diet on microRNA expression in the liver of  blunt snout bream (Megalobrama Amblycephala). PLoS One, 2014, 9  (5): e96132.

 

2003-2012 (Design microarrays to  identify DNA methylation markers for clinical diagnosis)            

1.  Min Pan, Qinyu Ge, Hailing Li, Qi Yang, Jiafeng Lu, Dingdong Zhang,  Zuhong Lu*. Sequencing the miRNAs in maternal plasma from women before and  after parturition. Journal of Nanoscience and Nanotechnology, 12: 1–9,  2012.

2.  Yunfei Bai, Dai Lin, Qin Han, Yaojuan Jia, Jing Tu, Junfeng Luo, Qinyu  Ge, Dingdong Zhang, Zuhong Lu*. Discrimination of single nucleotide  mutation by using a new class of immobilized shared-stem double-stranded DNA  probes. Journal of Biomedical Nanotechnology, 7:1–8, 2011.

3.  Yao Yang, Wei Wang, Yanqiang Li, Jing Tu, Yunfei Bai, Pengfeng  Xiao, Dingdong Zhang, Zuhong Lu*. Identification of methylated regions  with peak search based on Poisson model from massively parallel methylated DNA  immunoprecipitation sequencing data. Electrophoresis, 31: 3537–3544,  2010.

4. Dingdong  Zhang#, Yan Wang#, Yunfei Bai, Qinyu Ge, Yingjuan Qiao,  Junfeng Luo, Chao Jia, Zuhong Lu*. A novel method to quantify local CpG  methylation density by regional methylation elongation assay on  microarray. BMC Genomics, 2008, 9:59.

5.  Yan Wang#, Dingdong Zhang#, Wenli Zheng, Junfeng  Luo, Yunfei Bai, Zuhong Lu*. Multiple gene methylation of nonsmall cell lung  cancers evaluated with 3-dimensional microarray. Cancer, 2008,  112:1325-1336.

6. Dingdong  Zhang#, Yunfei Bai#, Yan Wang, Junfeng Luo, Qinyu Ge,  Yingjuan Qiao, Chao Jia, Zuhong Lu*. Detailed methylation patterns and  protein expression profiles of MGMT in colorectal carcinoma surgical  margins. Clinical Biochemistry, 2008, 41(1-2):19-25.

7.  Qinyu Ge, Yunfei Bai, Dingdong Zhang, Zuhong Lu*. Microarray Detection  of Fetal DNA Levels in Maternal Plasma. Analytical Letters, 2007, 40:  1540-1548.

8.  Qinyu Ge, Zhaobin Liu, Yunfei Bai, Dingdong Zhang, Pinfei Yu, Zuhong  Lu*. Emulsion PCR-based method to detect Y chromosome  microdeletions. Analytical Biochemistry, 2007, 367(2): 173-178.

9.  Zhixiang Wu, Junfeng Luo, Qinyu Ge, Dingdong Zhang, Yan Wang, Chao Jia,  Zuhong Lu*. Allele-specific extension on microarray for DNA methylation  analysis. Analytica Chimica Acta, 2007, 603(2):199-204.

10.Dingdong  Zhang, Yunfei Bai, Qinyu Ge, Yingjuan Qiao, Yan Wang, Zaozao Chen, Zuhong  Lu*. Microarray-based molecular margin methylation pattern analysis in  colorectal carcinoma. Analytical Biochemistry, 2006, 355(1):117-124.

11.Yan  Wang, Wenli Zheng, Junfeng Luo, Dingdong Zhang, Zuhong Lu*. In situ  bisulfite modification of membrane-immobilized DNA for multiple methylation  analysis. Analytical Biochemistry, 2006, 359(2): 183-188.

12.Wenli  Zheng, Yan Wang, Dingdong Zhang, Junfeng Luo, Zuhong Lu, A microarray to  analyze methylation patterns of E-cad gene 5’CpG islands, 4’th  International Forum of Post-Genome Technologies (IFPT’4), 286~290,  September 25-26, 2006, Hangzhou, China.

 

二、专利 (Patents)

1. 张定东,刘文斌,徐维娜,蒋广震,李向飞,孙存鑫,蔡万存. 一种鱼粉替代物及其制备方法与应用. 专利号:ZL201610013390.5  (20191105)

2. 孙存鑫,张定东,刘文斌,徐维娜,蒋广震,李向飞一种渔用复合型诱食剂及其制备方法与应用. 专利号:ZL201610104835.0  (20200825

3. 徐维娜,刘文斌,张定东,蒋广震,鲁康乐,秦钦.一种改善黄颡鱼鱼苗食性转换期肠道功能的微生态饲料.专利号:ZL201310103740.3  (2014507)

4. 李向飞,刘文斌,徐超,蒋广震,张定东. 一种改善鱼体糖耐受性的调控组合物及其制备方法与应用. 专利号:ZL201510811938.6  (20190226)

5. 蒋广震, 刘文斌, 周嫚, 李向飞张定东. 一种以甘草提取物为主的调控剂、及其制备方法与应用. 专利号:ZL201510843107.7  (20181123)

6. 李向飞,刘文斌,王冰柯,蒋广震,张定东. 一种渔用糖代谢调控物及其制备方法与应用. 专利号:ZL201610261110.22018918日)

7.  蒋广震;刘文斌;李向飞;张定东;米海峰;吴业阳. 一种维生素强化的团头鲂抗逆饲料的维生素添加剂.专利号:ZL201610215215.4  (20191112)

8.  刘文斌;何超凡;李向飞;张定东;蒋广震;郑肖川;黄洋洋;何畅. 一种浮性膨化饲料专用食台. 实用新型专利,专利号:ZL201922190568.5  (20210105)

 

 

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